Be that as it may, the disease, as will be subsequently seen in the accounts of those who lived at the time, showed itself in various ways. Some were struck suddenly, and died within a few hours; others fell into a deep sleep, from [p009] which they could not be roused; whilst others, again, were racked with a sleepless fever, and tormented with a burning thirst. The usual course of the sickness, when it first made its appearance, was from three to five days; but towards the close of the epidemic the recovery of those suffering from the carbuncular swellings was extended, as in the case of ordinary Eastern plague, over many months.[19] Such is a brief account of the disease which devastated the world in the middle of the fourteenth century. Before following the course of the epidemic in Italy, to which it was conveyed, as De' Mussi relates, from the Crimea, some account of its ravages in Constantinople and in Sicily may be given. From the Crimea Constantinople lay upon the highway to the west. Italian ships crossing the Black Sea [p010] would naturally touch at this city, then the great centre of communication between the Eastern and Western Worlds. From the relation of De' Mussi it appears that Caffa, the plague-stricken Genoese city in the Crimea, besieged by the Tartars, was in communication by ship with countries from which it received supplies. To Constantinople, therefore, it seems not unlikely that the dreaded disease was conveyed by a ship coming from this plague centre in the Crimea. An account of the pestilence at the Imperial city has come from the pen of the Emperor John Cantacuzene, who was an eye-witness of what he reports. And although he adopted the language of Thucydides, about the plague of Athens, to describe his own experiences at Constantinople, he could hardly have done so had the description not been fairly faithful to the reality. "The epidemic which then (1347) raged in northern Scythia," he writes, "traversed almost the entire sea-coasts, whence it was carried over the world. For it invaded not only Pontus, Thrace, and Macedonia, but Greece, Italy, the Islands, Egypt, Lybia, Judea, Syria, and almost the entire universe."