The man came under my care on a Sunday, the fast, which is the subject matter of this communication, having been commenced on the Friday six weeks before that day, the last food having been taken on the Thursday at 5 P.M. I saw him, therefore, on the forty-fifth day of the fast. His pulse was 59, soft, steady, regular. Temp. 96.8 degrees, about 11 A.M. He was able to be up, and walked actively, all his bodily movements being active and his mind quite clear and rational. His weight on the day after I first saw him was, in the same clothes as when weighed at the beginning of the fast, 129+1/2 lbs. He said he weighed 171 lbs. on the machine at the commencement, and therefore the loss of bodily weight up to that time was 41.5 lbs. The average loss of weight during the 46 days of the fast was about nine-tenths of a pound daily if the 41.5 lbs. loss is divided by the 46 days of the continuance of the fast up to that time--41.5/46=.9 lbs. almost exactly. When he came to my consulting room on the forty-sixth day, about 2.15 P.M., the pulse was 64, temp. 95.6 degrees (thermometer 3 minutes under tongue). He was much troubled with a nasty expectoration of mucus. His breath was very offensive. No enlarged glands could be felt in either groin--perhaps a trifling enlargement in the right. In middle of front border of right tibia a little irregularity is felt, and a small hollow, which he thinks is filling up; but it might be that the exudation on the bone immediately above and below the hollow is somewhat reduced, as this would equally give the suggestion that the hollow is filling up. There is a similar but rather smaller irregularity on the left tibia also. He felt rather weak that day, which he attributed to not having had his usual walk the day before. The nasal cavity consists of a large grey septumless cavern showing dry crusts. The issuing breath is most offensive. Patient had drunk freely of water, he said, to the extent of 4 or 5 quarts a day during the fast but when I said--do you mean that you have been taking over a gallon of water daily?--he rather hesitated, and did not think it was so much as that. He had not measured it and had taken it cold usually, though occasionally hot, and had taken it without stint as he wanted it. On the forty-eighth day of the fast he complained of being weak but worst of all, he said, his breath was very offensive to himself. It was so to me also--faint, fetid, putrid. His sense of smell was greatly impaired, so much so that he could not smell the offensiveness of the bowel-excreta which came away every day on using the gravitation-enema, and which were horrible to by-standers. It would seem from this as if his distress at the bad smell of his breath was probably due to a perversion of the sense of smell, which can be easily understood if we reflect that the disease-process was going on in the region where the smell-apparatus is specially located. The temperature was 96.2 degrees that morning the patient said.