His residence in Hamilton naturally made his name known to the Duke of Hamilton, whose palace is situated in the immediate vicinity of that town. His Grace being taken with a sudden illness, sent for Cullen, and was highly delighted with the sprightly character, and ingenious conversation of the young physician. He found no difficulty, especially as young Cullen was already known to the Duke of Argyle, in getting him appointed to a place in the University of Glasgow, where his singular talents as a teacher soon became very conspicuous. It was while Dr. Cullen was a practitioner in Shotts that he formed a connexion with William, afterwards Doctor Hunter, the famous lecturer on anatomy in London, who was a native of the same part of the country as Cullen. These two young men, stimulated by genius, though thwarted by the narrowness of their circumstances, entered into a copartnery business, as surgeons and apothecaries, in the country. The chief object of their contract was to furnish the parties with the means of carrying on their medical studies, which they were not able to do separately. It was stipulated that one of them, alternately, should be allowed to study in whatever college he preferred, during the winter, while the other carried on the common business in his absence. In consequence of this agreement, Cullen was first allowed to study in the University of Edinburgh, for a winter. When it came to Hunter’s turn next winter, he rather chose to go to London. There his singular neatness in dissecting, and uncommon dexterity in making anatomical preparations, his assiduity in study, his mild manners, and easy temper, drew upon him the attention of Dr. Douglas, who at that time read lectures on anatomy and midwifery in the capital. He engaged him as his assistant, and he afterwards succeeded him in the same department with much honour to himself, and advantage to the public. Thus was dissolved a copartnership of perhaps as singular a kind as any that occurs in the annals of science. Cullen was not disposed to let any engagement with him prove a bar to his partner’s advancement in the world. The articles were abandoned, and Cullen and Hunter kept up ever after a friendly correspondence; though there is reason to believe that they never afterwards met. It was while a country practitioner that young Cullen married a Miss Johnston, daughter of a neighbouring clergyman. The connexion was fortunate and lasting. She brought her husband a numerous family, and continued his faithful companion through all the alterations of his fortune. She died in the summer of 1786.