Amongst the chief diseases in which a pathognomonic condition of the blood has been discovered is the increase of the fibrine, which always takes place in inflammatory diseases, such as acute rheumatism and inflammation of the lungs; in low fevers it is diminished; it is also subject to variation in other diseases. In typhoid fever the diminution of salt and the increase of fibrine is very marked; and indeed in all inflammatory states of the system, especially of a sthenic type, the partial absence or variation of the amount of the chloride of sodium is a most important characteristic. No attention has, up to the present time, been given to the relation which the presence of the chloride of sodium in the blood bears to disease, at least not that I am aware of; and from what I have noticed it opens up a question which in time will be considered of some moment. As the chloride of sodium obviates the tendency of the fibrine to coagulate, and as its coagulation or solubility is quite dependent on its normal amount in the blood, it presents to us many varied points of interest, not only physiologically, but medicinally, though in this respect it has not yet been recognised as a curative agent. Whenever the blood is impoverished we may be tolerably certain that salt is, in a greater or lesser degree, absent, or below the standard, and that it is variable. Now in scrofula the blood is not only vitiated, but poor in the extreme, and there is a decrease of the fibrine; and that being the case, the constitution suffers in proportion, the affection showing itself in various ways, which unmistakably indicate the adynamic state of that fluid which permeates the whole frame. Scrofula and her twin sister struma, for there is a difference, are low forms of chronic inflammatory cachexia, and are never entirely recovered from. We may justly term them systemic diseases originating local morbid phenomena, and which are always liable to give rise to obscure attacks of an apparently serious nature, but which are considerably modified if the treatment be simply hygienic, judicious, and practical; scrofula is always tedious and prolonged, and therefore, as I have said before, we must not anticipate that because salt is of a nature somewhat antidotal to it and its attendant evils, that its effects are to be observable instantaneously, or that any very remarkable results must necessarily be obtained. It is the reverse; the effects are slow in the extreme, but the benefit is permanent—that is, if the treatment adopted be calculated to restore to the blood that constituent so necessary for health.