Difficulties in the procurement of a sufficient supply of material for anatomical instruction, coupled with the demand for clinical teaching which was beginning to be urged by the profession, forced themselves on the attention of the Medical Faculty of Transylvania before the year 1836-37. But in that year a determined effort was made, engineered and led by Professor Caldwell, to remove the Medical College to Louisville, that city having been induced by the earnest and eloquent appeals of Caldwell to offer it a large bonus. But for the early withdrawal of Doctor Dudley from this promising scheme, toward which he was at first inclined--because mainly of his difficulties in the supply of anatomical material--it would have been successful. But Doctor Dudley finally declined to remove, much to the mortification of Doctor Caldwell, who, in his last valedictory to the graduates of 1837, indulged in a very bitter impersonal-personal tirade against deception and mendacity, aimed at Doctor Dudley--not saying openly to his colleague "thou art the man"--but hoping "the cap would fit him" and find its place. The Trustees of the University, of course, and influential citizens, violently opposed the proposed change. Doctor Caldwell was arraigned before the Board on charges preferred by Doctor Dudley, the principal of which was that he had been engaged in the enterprise of originating a rival medical college in Louisville while he was yet a professor in the Transylvania College and under oath to support it. Doctor Caldwell, disdaining to answer the summons of the Board, was, after a long and full investigation of the evidence, dismissed from his chair in Transylvania. The Medical Faculty was then dissolved and reorganized.[48] Doctors Cooke and Yandell, and finally Doctor Short, joined Doctor Caldwell to aid in the establishment of the _Louisville Medical Institute_. Professors Dudley and Richardson and the assistant professors, Bush and Peter, remained in Lexington. The celebrated Professor John Eberle was called to the chair of Theory and Practice, but he died shortly after the delivery of his introductory lecture. Professor Thomas D. Mitchell was appointed to the chair of Chemistry, etc., and Doctor James C. Cross to that of the Institutes of Medicine.[49] DOCTOR JOHN ESTEN COOKE