In the winter of 1825-26, he attended the medical lectures in the University of Pennsylvania, with a view to improvement in his profession and in the art of teaching in it. While there he was invited by the late celebrated surgeon, George McClellan--to whom he had become favorably known--to take the chair of Anatomy in the new Jefferson Medical College, which McClellan and other members of the profession were engaged in organizing. This situation he occupied with success for two years, leaving it then to accept the chair of Anatomy in the School of Medicine of the University of Maryland in Baltimore, which had been vacated by Professor Granville Sharpe Pattison, in 1827. In Baltimore he soon acquired an extensive medical and surgical practice. On the death of Professor John B. Davidge he was transferred to the chair of Surgery. In the language of his biographer and colleague, Samuel C. Chew, M. D.: "In Baltimore he found a congenial home and when, at the age of fourscore, he was laid to rest among us, his name had been for a whole lifetime a household word throughout our State." When, in 1838, he accepted the inducement offered him by the Medical Faculty of Transylvania University to occupy the chair of the Theory and Practice of Medicine in their college at Lexington, Kentucky,[88] during the four months of the winter course of lectures, he did not abandon his residence in Baltimore, but at the close of each session returned to his professional work in that city. It was there especially, as a professor and practitioner of surgery, that his life-work was done. Doctor Smith was a man of remarkable mental activity, "acuteness of perception and extraordinary power of adaptation to circumstances as they might arise, promptness of action and untiring industry.... And yet with his great gifts there was about him a remarkable simplicity of character and a transparent ingenuousness which was as incapable of affectation as of falsehood." His forte was Surgery, yet his lectures here on the Theory and Practice of Medicine were exceedingly clear and instructive. One little peculiarity of his may be noticed. He never lectured without a small whalebone rod or pointer. Without this in his hand he seemed to fear the loss of continuity of his ideas. As remarked by his biographer, "his wand must always be at hand, for, like the magician's divining-rod, it seemed to have some mystic connection with the exercise of his powers."