During a long period the fur trade was an important factor in the world's commerce, and accordingly the friendship and favor of the natives were eagerly sought by the leading nations of Europe. Great use was made of whiskey and gunpowder as articles of trade. Demoralization was rapid. Many tribes were decimated and others wiped out entirely by the ravages of strong drink and disease, especially smallpox and cholera. The former was terribly fatal. The Indians knew nothing of its nature or treatment, and during the nineteenth century the tribes along the Mississippi and Missouri rivers suffered severely. Even in my own day I have seen and talked with the few desolate survivors of a thriving village. In the decade following 1840 cholera ravaged the tribes dwelling along the great waterways. Venereal disease followed upon the frequent immoralities of white soldiers and frontiersmen. As soon as the Indian came into the reservation and adopted an indoor mode of life, bronchitis and pneumonia worked havoc with him, and that scourge of the present-day red man, tuberculosis, took its rise then in overcrowded log cabins and insanitary living, together with insufficient and often unwholesome food. During this period there was a rapid decline in the Indian population, leading to the now discredited theory that the race was necessarily "dying out" from contact with civilization. It must always be borne in mind that the _first_ effect of association with the more advanced race was not improvement but degeneracy. I have no wish to discredit the statements of the early explorers, including the Jesuit priests; but it is evident that in the zeal of the latter to gain honor for their society for saving the souls of the natives it was almost necessary to represent them as godless and murderous savages--otherwise there would be no one to convert! Of course they were not angels, but I think I have made it clear that they were a God-fearing, clean, and honorable people before the coming of the white man. THE TRANSITION PERIOD