(h) A round-celled sarcoma of the neck—H. Montague—slight return in six months. (i) A recurrent sarcoma of the neck and tonsil—J. O. Roe—six months after treatment died of erysipelas. The mode of administration is cumulative. The injection is of course to be made under the most thorough antiseptic principles attainable. It is by far preferable to make the injection into the growth itself, although, if this is impossible, it may be introduced into the nearest accessible point, but in the latter case the dosage needs to be doubled. As a rule one-half drop is the initial dose, and this is increased one-half drop each succeeding day until toleration is reached. This is evidenced by the natural reactionary fever rising to 102° or 103° F. In such case the following dose should be the same as the preceding, and if it should again go so high reduce the next dose one-half drop. The dose is increased in this manner until the maximum is attained. When applied to the neoplasm itself 8 drops is the full dose, or if elsewhere, double that amount, 16 drops. This last amount is to be continued daily until the tumor has disappeared. The toxin may commence to reduce the tumor in a week, but its administration should not be abandoned in less than three weeks’ trial. The time necessary to effect a cure is very variable; occasionally the neoplasm will almost disappear in two weeks, while on the other hand it may take several months. The reactionary symptoms are a chill, followed by fever, generally lasting about three hours, although occasionally it may continue twelve hours; acute transitory swelling of tissues in the immediate vicinity of injection; usually myalgic pains commencing at point of injection and radiating frequently over the whole body; in the more severe reactions there is nausea or even vomiting—in my own case it produced a weakening menorrhagia. CASE.—Mrs. E. C., æt. thirty-four years. A tall, thin woman of neurotic temperament. _Family History._—Father had chronic bronchitis, but died of kidney disease. Mother was an invalid for seven years with rheumatism of hip and knee until death, which was caused by apoplexy; a sister died of gastric disease. The patient married eleven years; has two children living; boy at nine months died of entero-colitis; boy three and one-half years died of fall from window; two miscarriages. At ten years æt. the patient had diphtheria; at twenty-six, pleurisy; at thirty-one years, rheumatism of left shoulder and post-cervical region. It is impossible to obtain any indication of hereditary predisposition.