April 4. Commenced injections with one-quarter of a drop. I diminished the initial dose one-half because Dr. Coley personally advised it, as he thought the possible reactionary local swelling might seriously interfere with respiration. April 14. The dose was increased one-quarter drop each day to date—when she took only two drops, because it was deemed advisable to omit treatment two days during menstruation on account of great weakness of patient. April 20. Increased dose half drop per diem—on 16th and 19th treatment omitted on account of debility—dose 4 drops, which dose was continued till April 23, when on account of the temperature twice having risen to 103° F. and menorrhagia having supervened only ten days after previous regular menstruation, I thought it prudent to reduce dosage to 3½ drops, which was continued until April 26. Examination of pharynx to-day for first time showed a decided diminution in the congested appearance and size of the tumor. Formerly the tumor pushed the posterior pillar forward, so that, if the pillar could not have been lifted away from swelling by the ring probe, it would have seemed to be part of it; while to-day a small space could be distinguished between the tumor and the pillar. Dosage 4 drops. In _résumé_, I would call attention to the apparent susceptibility of the patient to the toxin. Because, although she never received over half the maximum dose, the following reactionary symptoms developed: Of the seventeen days on which full records were kept, on thirteen she had chills after every dose; there were muscular pains throughout the left side, occasionally extending to the right—one-third of the time the patient was nauseated, and three times vomited—the average temperature was 100.8° F.; twice it did not rise at all after injections of ½ or 2½ drops. ’Tis well to bear in mind that chills very seldom occur after the third injection. Finally, I wish to thank Dr. Clausen, resident physician, who carried out most of the treatment while the patient was at the Ophthalmic Hospital; also Dr. Bernard Clausen, who continued it after she returned home. REPORT ON “HENPUYE” IN THE GOLD COAST COLONY.[3] BY ALBERT J. CHALMERS, M. D., VICT., F. R. C. S. ENG.