Again, according to Meade, “It is not wonderful that disaffection should take place and dissent begin.” It was under these conditions and after Lord Howard of Effingham succeeded Culpepper in Virginia, having received royal instructions “to allow no person to use a printing press, on any occasion whatsoever,” that there came into Virginia the man whose influence in the cause of religious liberty in the colonies must be reckoned as second to that of but few others—this was Francis Makemie, the Irish founder of organized Presbyterianism in America. He came by the way of the Barbadoes and settled at Rehoboth by the river and founded the Presbyterian Church at Snow Hill, Maryland, 1683. He was earnest, fearless and indefatigable in his labors for the spiritual uplift of the people with whom his lot was cast, and it is worth noting that in those days of the intolerance of the established church, that the Presbyterian denomination began its existence in a colony founded by a Roman Catholic nobleman, Lord Baltimore. Having raised the blue banner in Maryland, he traveled by land as far as Norfolk and proceeded to Carolina, where it seems he labored among the people until the spring of the following year, as he was in North Carolina in May. In a letter to Increase Mather, written July 22d, 1684, from Elizabeth River, Virginia, he speaks of a voyage engaged to South Carolina, but he met with contrary winds and was driven as far north as Delaware Bay and eventually had to put into Virginia, where he was persuaded by Colonel Anthony Lawson and other inhabitants of the Parish of Linhaven in lower Norfolk County to stay that season. Their pastor, formerly from Ireland, died the August before and left them without a leader. Makemie seems to have remained at Elizabeth River for a considerable time. He writes again from there to Increase Mather, Boston, N. England, under date of July 28, 1685, in which he acknowledges the receipt of a letter and three books and refers to a Mr. Thomas Barret, a minister living in South Carolina and from whom he had received a letter from Ashley River, stating that he was about to take shipping for New England and for whom Makemie enclosed a letter. Just how long after this he remained with this people is not known, only that in the following year he made an extended preaching tour southward to Carolina, ministering to the spiritual necessaries of the people in neglected communities and performing the other duties devolving upon a true minister of the Gospel. It was no easy task that confronted him, while nearly three fourths of the population were dissenters from the established church. “It is safe to say,” says Cobbs, “that no small proportion of the people were without any definite religion.” This was especially true of North Carolina.