It has been urged that if Cesare was the elder of these two, he, and not Giovanni, would have succeeded to the Duchy of Gandia on the death of Pedro Luis--Cardinal Roderigo’s eldest son, by an unknown mother. But that does not follow inevitably; for it is to be remembered that Cesare was already destined for an ecclesiastical career, and it may well be that his father was reluctant to change his plans. Meanwhile the turbulent reign of Sixtus IV went on, until his ambition to increase his dominions had the result of plunging the whole of Italy into war. Lorenzo de’Medici had thwarted the Pope’s purposes in Romagna, coming to the assistance of Città di Castello when this was attacked in the Pope’s interest by the warlike Giuliano della Rovere. To avenge himself for this, and to remove a formidable obstacle to his family’s advancement, the Pope inspired the Pazzi conspiracy against the lives of the famous masters of Florence. The conspiracy failed; for although Giuliano de’Medici fell stabbed to the heart--before Christ’s altar, and at the very moment of the elevation of the Host--Lorenzo escaped with slight hurt, and, by the very risk to which he had been exposed, rallied the Florentines to him more closely than ever. Open war was the only bolt remaining in the papal quiver, and open war he declared, preluding it by a Bull of Excommunication against the Florentines. Naples took sides with the Pope. Venice and Milan came to the support of Florence, whereupon Milan’s attentions were diverted to her own affairs, Genoa being cunningly set in revolt against her. In 1480 a peace was patched up; but it was short-lived. A few months later war flared out again from the Holy See, against Florence this time, and on the pretext of its having joined the Venetians against the Pope in the late war. A complication now arose, created by the Venetians, who seized the opportunity to forward their own ambitions and increase their territories on the mainland, and upon a pretext of the pettiest themselves declared war upon Ferrara. Genoa and some minor tyrannies were drawn into the quarrel on the one side, whilst on the other Florence, Naples, Mantua, Milan, and Bologna stood by Ferrara. Whilst the papal forces were holding in check the Neapolitans who sought to pass north to aid Ferrara, whilst the Roman Campagna was being harassed by the Colonna, and Milan was engaged with Genoa, the Venetians invested Ferrara, forced her to starvation and to yielding-point. Thereupon the Pope, perceiving the trend of affairs, and that the only likely profit to be derived from the campaign would lie with Venice, suddenly changed sides that he might avoid a contingency so far removed from all his aims.