“Sire,--My researches on fermentations and on microscopic organisms have opened to physiological chemistry new roads, the benefit of which is beginning to be felt both by agricultural industries and by medical studies. But the field still to be explored is immense. My great desire would be to explore it with a new ardour, unrestrained by the insufficiency of material means. “I should wish to have a spacious laboratory, with one or two outhouses attached to it, which I could make use of when making experiments possibly injurious to health, such as might be the scientific study of putrid and infectious diseases. “How can researches be attempted on gangrene, virus or inoculations, without a building suitable for the housing of animals, either dead or alive? Butchers’ meat in Europe reaches an exorbitant price, in Buenos Ayres it is given away. How, in a small and incomplete laboratory, can experiments be made, and various processes tested, which would facilitate its transport and preservation? The so-called ‘splenic fever’ costs the Beauce[26] about 4,000,000 francs annually; it would be indispensable to go and spend some weeks in the neighbourhood of Chartres during several consecutive summers, and make minute observations. “These researches and a thousand others which correspond in my mind to the great act of transformation after death of organic matter, and the compulsory return to the ground and atmosphere of all which has once been living, are only compatible with the installation of a great laboratory. The time has now come when experimental science should be freed from its bonds....” The Emperor wrote to Duruy the very next day, desiring that Pasteur’s wish should be acceded to. Duruy gladly acquiesced and plans began to be drawn out. Pasteur, who scarcely dared believe in these bright hopes, was consulted about the situation, size, etc., of the future building, and looked forward to obtaining the help of Raulin, his former pupil, when he had room enough to experiment on a larger scale. The proposed site was part of the garden of the Ecole Normale, where the pavilion already existing could be greatly added to. In the meanwhile Pasteur was interviewed by the Mayor and the President of the Chamber of Commerce of Orleans, who begged him to come to Orleans and give a public lecture on the results of his studies on vinegar. He consented with pleasure, ever willing to attempt awakening the interest of the public in his beloved Science--“Science, which brings man nearer to God.”