The prophecy of the seventy weeks, which had hitherto been restricted to the first coming of our Saviour, is shown to be a prediction of all the main periods relating to the coming of the Messiah, the times of his birth and death, the time of his rejection by the Jews, the duration of the Jewish war by which he caused the city and sanctuary to be destroyed, and the time of his second coming. In the eleventh chapter Sir Isaac treats with great sagacity and acuteness of the time of our Saviour’s birth and passion,—a subject which had perplexed all preceding commentators. After explaining in the twelfth chapter the last prophecy of Daniel, namely, that of the scripture of truth, which he considers as a commentary on the vision of the ram and he-goat, he proceeds in the thirteenth chapter to the prophecy of the king who did according to his will, and magnified himself above every god, and honoured Mahuzzims, and regarded not the desire of women. He shows that the Greek empire, after the division of the Roman empire into the Greek and Latin empires, became the king who in matters of religion did according to his will, and in legislation exalted and magnified himself above every god. In the second part of his work on the Apocalypse of St. John, Sir Isaac treats, _1st_, Of the time when the prophecy was written, which he conceives to have been during John’s exile in Patmos, and before the epistle to the Hebrews and the epistles of Peter were written, which in his opinion have a reference to the Apocalypse; _2dly_, Of the scene of the vision, and the relation which the Apocalypse has to the book of the law of Moses, and to the worship of God in the temple; and, _3dly_, Of the relation which the Apocalypse has to the prophecies of Daniel, and of the subject of the prophecy itself. Sir Isaac regards the prophecies of the Old and New Testaments, not as given to gratify men’s curiosities, by enabling them to foreknow things, but that after they were fulfilled, they might be interpreted by the event, and afford convincing arguments that the world is governed by Providence, he considers that there is so much of this prophecy already fulfilled as to afford to the diligent student sufficient instances of God’s providence; and he adds, that “among the interpreters of the last age, there is scarce one of note who hath not made some discovery worth knowing, and thence it seems one may gather that God is about opening these mysteries. The success of others,” he continues, “put me upon considering it, and if I have done any thing which may be useful to following writers, I have my design.” Such is a brief abstract of this ingenious work, which is characterized by great learning, and marked with the sagacity of its distinguished author. The same qualities of his mind are equally conspicuous in his _Historical Account of Two Notable Corruptions of Scripture_.