Theobromine is a permanent white powder, appears under the magnifying glass as small, white, prismatic or granular crystals. At first it has only a slightly bitter taste, which becomes more intense when it is kept in the mouth for some length of time; and indeed, the bitter taste of the cacao bean and its preparations is mostly due to theobromine. It sublimes at 220 ° C. without melting. This phenomenon explains why the over roasted bean, that is, the kernel of beans which by accident have been heated to more than 130-150 ° C. is poorer in theobromine than the husks. When heated to 310 ° C. theobromine melts to a clear liquid which re-crystallizes on cooling. One part of absolutely pure theobromine dissolves according to Eminger in 736·5 parts of water at 18 ° C., in 136 parts at 100 ° C. in 5399 parts alcohol (90 %) at 18 ° C. in 440 parts at boiling (90 %) point and in 818 parts of boiling absolute alcohol. It dissolves in 21000 parts of ether at 17 ° C. in 4856 parts of methyl alcohol at 18 ° C. in 58·8 parts of chloroform at 18 ° C. and in 2710 parts of boiling chloroform[63]. Theobromine is partly decomposed by strong alkalis but by cautious addition of alkalis it forms compounds with them, which, are readily dissolved by solutions of sodium salicylate, acetate or benzoate. These double compounds under the name of diuretin, agurin and uropherin have lately become of therapeutic value.[64] Sodium silicate and more particularly trisodiumphosphate according to Brissemoret[65] are great solvents of theobromine. One and a half molecules of the latter salt can dissolve one molecule of theobromine so that in this way it is possible to prepare a solution of nearly 2 percent. Phenol also dissolves a large quantity of theobromine, according to Maupy,[66] who has utilised this property for the determination of theobromine. The defatted cacao preparation is moistened with water and extracted with a mixture consisting of 15 percent of phenol and 85 percent of chloroform. Theobromine, like caffeine, gives the so called murexide reaction when evaporated with chlorine water—forming amalic acid—and when a watch glass previously moistened with a little fluid ammonia is held over the last few drops at the end of the operation. The residue thus obtained has a violet colour, which serves to distinguish theobromine readily from other plant bases which do not belong to the xanthine group. Although theobromine is the most valuable constituent of cacao beans, the importance attached to a greater or lesser amount in the beans as a commercial article was formerly much exaggerated.