There are the same structural changes in the evolution of insanity as in that of catarrh. There is a morbid structural basis in minds diseased, the abnormal mentality or morality being merely symptoms of a physical disease. Of all human legacies, structural weakness of the mental or moral sense is the most unfortunate. I shall say no more about the forms of mental disease than that there is distinctively both intellectual and moral insanity as a direct result of disease of the intellectual and moral centres. This will be more clearly seen when I recall the fact that moral insanity in its worse form--the suicidal--often exists with such intellectual clearness that there is the greatest ingenuity displayed in carrying out self-destruction. These mind and soul centres are often gravely diseased without impairment of muscle energy: the furious strength of the insane is an abiding fear with all. It is clear that weakness of structure so soft as brain, a substance which is on the dividing-line between liquids and solids, must be of the gravest form from the first: grave because so fragile, grave because the sick centres cannot rest as the broken arm, the sick body: these centres, regardless how sick, must continue to serve, even in abnormal ways. The possibility of insanity must always be a matter of the degree of the primary structural weakness and the energy and persistence of the operative forces; on these must depend the mere gentle, persistent illusion, or that fury of mania which transforms man, the "image of the Creator," into a wild beast. That insanity, no matter what its form or degree, is an evolution from an ancestral structural legacy, not essentially different from the structural conditions evolved from those of any other chronic disease, I cannot have the slightest doubt, any more than I can have for the structural means for the cure. There is nothing that so illustrates the civilization, the benevolence of the age and of the nations as these palaces we call hospitals for the insane. Whatever there is that can add comfort to the body, or charm to the tastes, or new life to the soul has its culmination in these palaces of wood and stone, with one great exception: the structural condition of the diseased centres indicating rest, even as the ulcer, wound, or fracture, has no part in the methods of cure.