During the severer period of the disorder, he had no opportunity of attempting such a crime, as he universally insisted on both food and medicine being both prepared and administered by the nurses; he himself rendered every assistance in the endeavour to detect any such attempt when its possibility had been suggested by myself; and lastly, Madame R** did not die, although the investigation had already removed all suspicion. I think such an imputation wholly unwarranted and unwarrantable from any one circumstance of the case. 5.--_Extracts from Dr. Marsden's Diary_[5] MAY 23rd.--Madame R**, nausea, vomiting, tendency to diarrhoea, profuse perspiration, and general debility. Pulse low, 100. Spirits depressed. Burning pain in stomach--abdomen tender on pressure. Tongue discoloured. 26th.--Madame R** slightly better--less nausea and pain. 30th.--Madame R**. Improvement continues. JUNE 2nd.--Madame R** improving. 6th.--Ditto. 9th.--Recurrence of symptoms on Saturday evening.[6] Increased nausea, vomited matter yellow with bile. Pulse low, 105. Throat sore, and slight constriction. Tongue foul. 13th.--Symptoms slightly ameliorated. Treatment continued. 16th.--Ditto. Tongue slightly clearer. Pulse 100. 20th.--Improvement continued. Pulse slightly firmer. 23rd.--Ditto. 24th.--Special visit. Return of symptoms last night. Great increase of nausea and vomiting--very yellow with bile. Throat sore and tongue foul. Abdomen very tender on pressure. Slight diarrhoea. Tingling sensation in limbs. 27th.--Slight improvement. 30th.--Continued, but slight. Pulse firmer. JULY 3rd.--Improvement continued, especially in throat. Perspiration still distressing. Less tingling in limbs. 6th.--Improvement continued. Pulse somewhat firmer, 110. (10th to 20th.--Absent in Gloucestershire.) 20th.--A slight rally. Baron says attack shortly after last visit, but recovery for time more rapid. 24th.--Improvement continues, but less rapid. Pulse 110. 27th.--Recurrence yesterday. Vomiting, purging amounting to diarrhoea. Soreness and aphthous state of mouth and throat. Perspiration. Pain in abdomen. Complains of taste in mouth like lead. Pulse low, 115. Qy. antimony? Speak, Baron. 31st.--Analysis--satisfactory. Symptoms slightly abated. AUGUST 3rd.--Improvement continued. Pulse 112, firmer. 7th.--Same. 10th.--Return of vomiting and purging. General aggravation of symptoms. Much prostrated. 24th, 28th, 31st.--Slight improvement. SEPTEMBER 4th.--Improvement continued, but slight. 7th.--Return of severe symptoms. Vomiting, extremely yellow, much bile. Diarrhoea. Pulse low and fluttering, 120. Violent perspiration. Slight wandering. Extreme soreness and constriction of throat. Slight convulsive twitchings in limbs. Great exhaustion and prostration. 10th, 14th, 18th.--Very slight abatement of symptoms. 21st.--Violence of symptoms increased. Pulse 125. Great prostration. 25th, 28th.--Very slight amelioration. Pulse 125. Wandering.