The nutrition of manChittenden, R. H. (Russell Henry)
Science
The nutrition of man
Chittenden, R. H. (Russell Henry)
Nutrition
Here we see, as would be expected, that on the high proteid diet, there
was a large excretion of total nitrogen and of urea; while on the low
proteid diet, nitrogen and urea were correspondingly diminished. The
point to attract our attention, however, is the marked difference in
the percentage of urea-nitrogen in the two cases; a difference which
amounts to about 26 per cent. A similar difference is to be noted in
the percentage of uric acid-nitrogen. Lastly, it is to be observed that
in spite of the great difference in the extent of metabolism on the
two days--an excretion of 16.8 grams of nitrogen, as contrasted with
3.6 grams--the _amount_ of creatinin-nitrogen is essentially the same.
Folin finds that these peculiarities in the percentage distribution
of excreted nitrogen hold good in all cases where there is this wide
divergence in the amount of proteid katabolized, and, further, that
there is a gradual and regular transition from the one extreme to the
other. He sees in these results evidence that there are in the body
two forms of proteid katabolism, essentially independent and quite
different. One kind is extremely variable in quantity, while the other
tends to remain constant. The variable form has its own particular
kind of waste products, of which urea is the chief. The constant
katabolism, on the other hand, is largely represented by creatinin
and to a lesser degree by uric acid. The more the total katabolism is
reduced, the more prominent become creatinin and uric acid, products
of the constant katabolism; while urea, as chief representative of the
variable katabolism, becomes less conspicuous. Folin suggests the term
_endogenous_ or _tissue_ metabolism for the constant variety, while the
variable form he would name _exogenous_ or _intermediate_ metabolism.
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