For the week I was dropping from sixteen grains to nine the addition of new symptoms was slight, but the aggravation of the pain previously endured was marked. The feeling of bodily and mental wretchedness was perpetual, while the tedium of life and occasional vague wishes that it might somehow come to an end were not infrequent. The chief difficulty was to while away the hours of day-light. My rest at night had indeed become imperfect and broken, but still it was a kind of sleep for several hours, though neither very refreshing nor very sound. Those who were about me say that I was in constant motion, but of this I was unconscious. I only recollect that wakening was a welcome relief from the troubled activity of my thoughts. After my morning's ride I usually walked slowly and hesitatingly to the city, but as this occupied only an hour the remaining time hung wearily upon my hands. I could not read--I could hardly sit for five consecutive minutes. Many suffering hours I passed daily either in a large public library or in the book-stores of the city, listlessly turning over the leaves of a book and occasionally reading a few lines, but too impatient to finish, a page, and rarely apprehending what I was reading. The entire mental energies seemed to be exhausted in the one consideration--how not to give in to the tumult of pain from which I was suffering. Up to this time I had from boyhood made a free use of tobacco. The struggle with opium in which I was now so seriously engaged had repeatedly suggested the propriety of including the former also in the contest. While the severity of the struggle would, I supposed, be enhanced, the self-respect and self-reliance, the opposition and even obduracy of the will would, I hoped, be enough increased as not seriously to hazard the one great object of leaving off opium forevcr. Still I dreaded the experiment of adding a feather's weight to the sufferings I was then enduring. An accidental circumstance, however, determined me upon making the trial; but to my surprise, no inconvenience certainly, and scarce a consciousness of the deprivation accompanied it. The opium suffering was so overwhelming that any minor want was aimost inappreciable. The next day brought me down to nine grains of Opium. It was now the sixteenth day of December, and I had still fifteen days remaining before the New Year would, as I had resolved, bring me to the complete relinquishment of the drug. The three days which succeeded the disuse of tobacco caused no apparent intensification of the suffering I had been experiencing. On the fourth day, however, and for the fortnight which succeeded, the agony of pain was inexpressibly dreadful, except for the transient intervals when the effects of the opium were felt.