The eccentricities of no man in America who has been at all conspicuous in public life approach the eccentricities of the late John Randolph of Roanoke. Diseased from his birth, with a temperament of the most excitable kind, he seems during the greater part of his days to have lived only just without the bounds of confirmed insanity. His constitutional infirmities were peculiarly the infirmities that find relief in opium; and it has generally been understood that his addiction to the habit was of many years' continuance and lasted to his death. I have been assured by a Virginia gentleman that when, in one of his last days, he directed his servant to write upon a card for his inspection the word "REMORSE," Randolph was understood to have in mind his excessive use of opium. His biographer, Mr. Hugh Garland, however, has given apparently as little prominence to his habit in this respect as was consistent with any mention of it whatever. The letters which follow contain nearly all the information that we can gather from this source. Under date of February, 1817, Randolph says: "The worst night that I have had since my indisposition commenced. It was, I believe, a case of _croup_ combined with the affection of the liver and the lungs. Nor was it unlike tetanus, since the muscles of the neck and back were rigid, and the jaw locked. I never expected, when the clock struck two, to hear the bell again. Fortunately, as I found myself going, I dispatched a servant (about one) to the apothecary for an ounce of laudanum. Some of this, poured down my throat, through my teeth, restored me to something like life. I was quite delirious, but had method in my madness; for they tell me I ordered Juba to load my gun and to shoot the first 'doctor' that should enter the room; adding, 'they are only mustard-seed, and will serve just to sting him.' Last night I was again very sick; but the anodyne relieved me. I am now persuaded that I might have saved myself a great deal of suffering by the moderate use of opium." Under date of March of the same year he writes to a friend: "No mitigation of my worst symptoms took place until the third day of my journey, when I threw physic to the dogs, and instead of opium, etc., I drank, in defiance of my physician's prescription, copiously of cold spring water, and ate plentifully of ice. Since that change of regimen my strength has increased astonishingly, and I have even gained some flesh, or rather skin." In a letter to Dr. Brockenbrough, dated May 30, 1828: