"I write again to tell you that extremity of suffering has driven me to the use of what I have had a horror all my life--I mean opium--and I have derived more relief from it than I could have anticipated. I took it to mitigate severe pain, and to check the diarrhea. It has done both; but to my surprise it has had an equally good effect upon my cough, which now does not disturb me in the night, and the diarrhea seldom until toward day-break, and then not over two or three times before breakfast, instead of two or three-and-thirty times. His biographer, speaking of the state of his health in the autumn of 1831, says, "Mr. Randolph made no secret of his use of opium at this time: 'I live by if not upon opium,' said he to a friend. He had been driven to it as an alleviation of a pain to which few mortals were doomed. He could not now dispense with its use. 'I am fast sinking,' said he, 'into an opium-eating sot, but, please God! I will shake off the incubus yet before I die; for whatever difference of opinion may exist on the subject of suicide, there can be none as to _rushing into the presence of our Creator_ in a state of drunkenness, whether produced by opium or brandy.' To the deleterious influence of that poisonous drug may be traced many of the aberrations of mind and of conduct so much regretted by his friends during the ensuing winter and spring. But he was by no means under its constant influence." WILLIAM WILBERFORCE. So little is known, beyond what appears in the following brief notices, of the opium habits of this distinguished philanthropist, that their citation here would be of little service to opium-eaters, except as they tend to show that the regular use of the drug in small quantities may sometimes be continued for many years without apparent injury to the health, while the same difficulty in abandoning it is experienced as attends its disuse by those whose moderation has been less marked. The son of Wilberforce, in the "Life" of his distinguished father, says: "His returning health was in a great measure the effect of a proper use of opium, a remedy to which even Dr. Pitcairne's judgment could scarcely make him have recourse; yet it was to this medicine that he now owed his life, as well as the comparative vigor of his later years. So sparing was he always in its use, that as a stimulant he never knew its power, and as a remedy for his specific weakness he had not to increase its quantity during the last twenty years he lived. 'If I take,' he would often say,'but a single glass of wine, I can feel its effect, but I never know when I have taken my dose of opium by my feelings.' Its intermission was too soon perceived by the recurrence of disorder." In a letter from Dr. Gilman, already quoted in the "Reminiscences of Coleridge," he says, speaking of the difficulty of leaving off opium, "I had heard of the failure of Mr. Wilberforce's case under an eminent physician of Bath," etc. A HALF CENTURY'S USE OF OPIUM.