"All this time you continued to absorb an agent which directly acts for what by a paradox may be called fatal conservation of the tissues. Whether through its complexly combined nitrogen, carbon, or both, the drug has interposed itself between your very personal substance and those oxidations by which alone its life can be maintained. It has slowed the fires of your whole system. It has not only interposed but in part it has substituted itself; so that along with much effete matter of the body stored away there always exists a certain undecomposed quantity of the agent which sustains this morbid conservation. [Footnote: I frequently use what hydropaths call "a pack" to relieve opium distress, and with great benefit. After an hour and a half of perspiration, the patient being taken out of his swaddlings, I have found in the water which was used to wash out his sheet enough opium to have intoxicated a fresh subject. This patient had not used opium for a fortnight.] "When this combination became established, you began losing your appetite because no substitution of fresh matter was required by your body for tissue wrongly conserved. The progressive derangement of your liver manifested itself in increased sallowness of face and cornea; the organ was working on an inadequate vital supply because the organic nervous system was becoming paralyzed; the veins were not strained of that which is the bowels' proper purgative and the blood's dire poison. You had sealed up all but a single excretory passage--the pores of the skin. Perhaps when you had opium first given you you were told that its intent was the promotion of perspiration but did not know the _rationale._ The only way in which opium promotes perspiration is by shutting up all the other excretory processes of the body, and throwing the entire labor of that function upon the pores. (When the skin gives out the opium-eater is shut up like an entirely choked chimney, and often dies in delirium of blood- poisoning.) "For a while--the first six years, perhaps--your skin sustained the work which should have been shared by the other organs--not in natural sweat, but violent perspiration, which showed the excess of its action. Then your palms became gradually hornier--your whole body yellower--at the same time that your muscular system grew tremulous through progressively failing nervous supply. "About this time you may have had some temporary gastric disturbance, accompanied with indescribable distress, loathing at food, and nausea. This indicated that the mucous lining of the stomach had been partially removed by the corrosions of the drug, or that nervous power had suddenly come to a stand-still, which demanded an increase of stimulus. "Since that time you have been taking your daily dose only to preserve the _status in quo_. The condition both of your nervous system and your stomach indicate that you must always take some anodyne to avoid torture, and _your_ only anodyne is opium.