Brandy and bitters after a few day's use had been abandoned, under the apprehension that they were connected with the tendency to internal inflammation which I have noticed as possibly affecting the brain. For a day or two I resorted to ale, but a disagreeable sweetness about it induced the substitution of Schenck beer, a weak kind of _lager_. This I found satisfied the craving for a bitter liquid, and it became for two or three weeks my chief drink. I should have mentioned that the day subsequent to the disuse of tobacco I had also given up tea and coffee, partly from a disposition to test the strength of my resolution, and partly from the belief that they might have some connection with a constant sensation in the mouth as if salivated with mercury. I soon learned that the real difficulty lay in the liver, and that this organ is powerfully affected in persons abandoning the long-continued use of opium. Had I known this fact at an earlier day it would have been of service in teaching me to control the diseased longing for rich and highly-seasoned food which had now become a passion. Eat as much as I would, however, the sense of hunger never left me; and this diseased craving, in ignorance of its injurious effects, was gratified in a way that might have taxed unimpaired powers of digestion. At length the long-anticipated New Year's Day, on which I was to be emancipated forever from the tyranny of opium, arrived. For five weeks of such steady suffering as the wealth of all the world would not induce me to encounter a second time, I had kept my eye steadily fixed upon this day as the beginning of a new life. This was also the day on which I was to dine with my friend. As the dinner-hour approached it became evident that no opium meant no dinner, and a little later, that dinner or no dinner the opium was still a necessity. A half grain I thought might carry me through the day, but in this I was mistaken. As I lay upon my friend's sofa, suffering from a strange medley of hunger, pain, and weakness, it seemed that years must elapse before the system could regain its tone or the bodily sensations become at all endurable. Soon after dinner I felt obliged to take another half-grain. My humiliation in failing to triumph when and how I had resolved to do, was excessive. In spite of the strongest resolutions, I was still an opium-eater. I somehow felt that after all I had gone through I ought, to have succeeded. I was in no mood to speculate about the causes of the failure; it was enough to know that I had failed, and what was worse, that apparently nothing whatever had been gained in the last four days. While I certainly felt no temptation to give in, I thought it possible that some of the functions of the body, from the long use of opium, might have completely lost their powers of normal action, and that I should be obliged to continue a very moderate use of the drug during the remainder of my life. I saw, in