first day for nearly ten years that I had existed without opium. I persevered in my abstinence for ninety hours; that is, upward of half a week. Then I took--ask me not how much; say, ye severest, what would ye have done? Then I abstained again; then took about twenty-five drops; then abstained; and so on. Meantime the symptoms which attended my case for the first six weeks of the experiment were these enormous irritability and excitement of the whole system--the stomach, in particular, restored to a full feeling of vitality and sensibility, but often in great pain; unceasing restlessness night and day; sleep--I scarcely knew what it was--three hours out of the twenty-four was the utmost I had, and that so agitated and shallow that I heard every sound that was near me; lower jaw constantly swelling; mouth ulcerated; and many other distressing symptoms that would be tedious to repeat, among which, however, I must mention one because it had never failed to accompany any attempt to renounce opium, viz., violent sternutation. This now became exceedingly troublesome; sometimes lasting for two hours at once, and recurring at least twice or three times a day. I was not much surprised at this, on recollecting what I had somewhere heard or read, that the membrane which lines the nostrils is a prolongation of that which lines the stomach, whence I believe are explained the inflammatory appearances about the nostrils of dram-drinkers. The sudden restoration of its original sensibility to the stomach expressed itself, I suppose, in this way. It is remarkable, also, that during the whole period of years through which I had taken opium I had never once caught cold--as the phrase is--nor even the slightest cough. But now a violent cold attacked me, and a cough soon after. In an unfinished fragment of a letter begun about this time to ----, I find these words: "You ask me to write the ---- ----. Do you know Beaumont and Fletcher's play of 'Thierry and Theodoret?' There you will see my case as to sleep; nor is it much of an exaggeration in other features. I protest to you that I have a greater influx of thoughts in one hour at present than in a whole year under the reign of opium. It seems as though all the thoughts which had been frozen up for a decade of years by opium, had now, according to the old fable, been thawed at once, such a multitude stream in upon me from all quarters. Yet such is my impatience and hideous irritability, that for one which I detain and write down fifty escape me. In spite of my weariness from suffering and want of sleep I can not stand still or sit for two minutes together. _'I nunc, et versus tecum meditare canoros.'"_