At this stage of my experiment I sent to a neighboring surgeon, requesting that he would come over to see me. In the evening he came, and after briefly stating the case to him I asked this question: Whether he did not think that the opium might have acted as a stimulus to the digestive organs, and that the present state of suffering in the stomach--which manifestly was the cause of the inability to sleep--might arise from indigestion? His answer was, No: on the contrary, he thought that the suffering was caused by digestion itself, which should naturally go on below the consciousness, but which, from the unnatural state of the stomach, vitiated by so long a use of opium, was become distinctly perceptible. This opinion was plausible, and the unintermitting nature of the suffering disposes me to think that it was true; for if it had been any mere _irregular_ affection of the stomach it should naturally have intermitted occasionally, and constantly fluctuated as to degree. The intention of Nature, as manifested in the healthy state, obviously is to withdraw from our notice all the vital motions--such as the circulation of the blood, the expansion and contraction of the lungs, the peristaltic action of the stomach, etc.--and opium, it seems, is able in this as in other instances to counteract her purposes. By the advice of the surgeon I tried _bitters_. For a short time these greatly mitigated the feelings under which I labored, but about the forty-second day of the experiment the symptoms already noticed began to retire and new ones to arise of a different and far more tormenting class. Under these, but with a few intervals of remission, I have since continued to suffer; but I dismiss them undescribed tracing circumstantially any sufferings from which it is removed by too short or by no interval. To do this with minuteness enough to make the review of any use would be indeed "_infandum renovare dolorem_," and possibly without a sufficient motive; for, secondly, I doubt whether this latter state be any way referable to opium, positively considered, or even negatively; that is, whether it is to be numbered among the last evils from the direct action of opium or even among the earliest evils consequent upon a _want_ of opium in a system long deranged by its use. Certainly one part of the symptoms might be accounted for from the time of year (August); for, though the summer was not a hot one, yet in any case the sum of all the heat _funded_ (if one may say so) during the previous months, added to the existing heat of that month, naturally renders August in its better half the hottest part of the year; and it so happened that the excessive perspiration which even at Christmas attends any great reduction in the daily quantum of opium, and which in July was so violent as to oblige me to use a bath five or six times a day, had about the setting in of the hottest season wholly retired, on which