The Organism as a Whole, from a Physicochemical ViewpointLoeb, Jacques
Science
The Organism as a Whole, from a Physicochemical Viewpoint
Loeb, Jacques
Biology; Life (Biology); Mendel's law
Since each daughter nucleus of a dividing blastomere has the same
number of chromosomes as the original nucleus of the egg, it is clear
that in a normally fertilized egg each nucleus has twice the mass of
chromosomes that is contained in the nucleus of a merogonic egg, _i. e._,
an enucleated fragment of protoplasm into which a spermatozoön
has entered and which is able to develop. Such a fragment has only
the sperm nucleus. This phenomenon of merogony was discovered by
Boveri and was elaborated by Delage.[172] Boveri, in comparing the
final size of the cells in normal and merogonic eggs after the cell
divisions had come to a standstill, found that this size is always
in proportion to the original mass of the chromatin contained in the
egg; the cells of the merogonic embryo, _e. g._, the mesenchyme cells,
are only half the size of the same cells in the normally fertilized
embryo. Driesch furnished a further proof of Boveri’s law, that the
final ratio of the mass of the chromatin substance in a nucleus to the
mass of protoplasm is a constant in a given species. Driesch compared
the size of the mesenchyme cells in a sea-urchin embryo produced by
artificial parthenogenesis with those of a normally fertilized egg and
found them half of the size of the latter. When the fertilized eggs and
the parthenogenetic eggs are equal in size from the start,--which is
practically the case if eggs of the same female are used,--the process
of the formation of mesenchyme cells comes to a standstill when their
number in the normally fertilized eggs is half as large as the final
number in the parthenogenetic egg.[173] Boveri’s results as well as
those of Driesch were obtained by counting the cells formed by eggs of
equal size and not by simply measuring the size of the cells. It is
most remarkable that certain apparent exceptions to Boveri’s law which
Driesch has actually found had been predicted by Boveri.
[172] Delage, Y., _Arch. Zoöl. expér._, 1899, vii., 383.
[173] Driesch, H., _Arch. f. Entwcklngsmech._, 1905, xix., 648.
These facts show that the growth of an organ comes to a standstill when
a certain size is reached or a certain number of cells are formed. We
cannot yet state why this should be, but we are able to add that the
formation of a lens of normal size in the regeneration of the eye is
in harmony with the phenomena in the embryo. There seems therefore
no reason for stating that the regeneration of the lens cannot be
explained on a purely physicochemical basis. The only justification for
such a statement on the part of Wolf is that he was not in possession
of the more complete set of facts now available through the work of
Fischel and Uhlenhuth.
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