The pathology of influenzaWinternitz, M. C. (Milton C.)
Science
The pathology of influenza
Winternitz, M. C. (Milton C.)
Influenza
FIG. XXVI. AUTOPSY NO. 103. THE LARGER ILLUSTRATION OF AN HEMORRHAGIC
ALVEOLAR EXUDATE IS ELABORATED BY TWO HIGHER POWER DRAWINGS. THESE
SHOW (1) AN ANEURSYMAL DILATATION OF A CAPILLARY IN THE ALVEOLAR
WALL AND (2a) A RUPTURE OF THE CAPILLARY WALL WITH THE ESCAPE OF RED
BLOOD CELLS INTO THE ALVEOLUS; (2b) NECROSIS WITH EARLY THROMBOSIS
OF THE CAPILLARY IN THE ALVEOLAR WALL.
]
It is probable that chronic processes, not sufficiently severe to
terminate fatally in a few weeks or months, may occur, but few examples
of that kind have been observed. A total of twelve cases of our series
in which organization of the bronchiolar (47), or alveolar exudate (156)
was found, include three of the lobar, three of the pseudolobar, two of
the lobular, and four of the peribronchial types. Such a
differentiation, it will be understood, is purely arbitrary. The
majority of the cases show, not only a reparative process, but also a
continuance of the acute change, and, indeed, both gross and microscopic
pictures of the lung may be complicated. It will be impossible to give
an inclusive description of these changes, and therefore a few of the
most diverse and characteristic will be presented in the form of case
abstracts.
_Autopsy No. 140._
A white female, aged 19 years, entered the New Haven Hospital after
five days of fever, prostration, and cough. She was moderately
cyanotic and dyspnœic, but examination of the lungs was negative
except for a few râles at the right base. She was delivered of a
six-months’ fœtus two days later. On the eleventh day of her
illness, definite signs of consolidation had developed in the
midback on both sides and spread gradually to include the left base
and all of the right back to the level of the 4th dorsal spine. The
temperature varied irregularly between 100°F. and 105°F. The pulse
followed the temperature, but averaged 102 per minute, while the
respirations remained about 40 per minute.
The white blood count on admission was 5,800, but rose gradually to
28,320 cells per cubic millimeter, with 90% of polymorphonuclear
leucocytes. The patient died on the twenty-second day of the
disease.
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