The pathology of influenzaWinternitz, M. C. (Milton C.)
Science
The pathology of influenza
Winternitz, M. C. (Milton C.)
Influenza
Her temperature at entrance was 104°F., and it fell by lysis to 99°F.
just before operation. After the operation it fell to 97°F., and in a
few hours rose to 99°F. Thirty-six hours after operation she had a chill
lasting ten minutes, and her temperature rose to 105°F. in eight hours,
when death occurred. The respirations were thirty per minute until the
rupture of the bladder when they rose to forty per minute and
corresponding to the final rise in temperature rose to 60 per minute.
The pulse ran a parallel curve to the temperature, ranging from 100 to
160 per minute.
The autopsy was held two hours after death, and the essential findings
were as follows:—
The body was that of a moderately obese woman. Rigor mortis had not
developed, but there was a distinct heliotropic hue of the face and
neck. The recent surgical wound between the symphysis pubis and
umbilicus was in good condition. The peritoneum was slightly dulled in
the lower half of the abdomen, and there was about 100 cubic centimeters
of faintly cloudy, blood-tinged, thin fluid in the pelvis. The left
pleural cavity contained about 200 cubic centimeters of slightly turbid,
amber fluid, but the right side was free from fluid. While the pneumonia
had not been prominent clinically, both lungs were found extensively
involved by a necrotizing and organizing bronchopneumonia with purulent
bronchitis similar to what has already been described. As the lesion of
the bladder is the distinctive one in this case, and as the other organs
show nothing that has not been described elsewhere, further description
will be confined to it.
The wall of the bladder was thin and soft, and grossly the sutured wound
appeared in good condition. Posteriorly there was a hemorrhagic zone
about 3 centimeters in width most marked beneath the mucosa, but
involving all of the coats. The mucosa was superficially ulcerated along
this area, and was covered by a thin, patchy, fibrinous exudate. In
addition, there were scattered beneath the mucosa several smaller
hemorrhagic foci, quite distinct from the larger one.
Microscopically, one striking feature was the erosion of the mucosa,
with hemorrhages most marked along the line of rupture but occurring
elsewhere in the subjacent tissues. This condition was found in all the
sections studied. Another feature was the lack of inflammatory exudate
and the very slight attempt to repair the injury, only a very rare
polymorphonuclear cell and fibroblast being seen. Sections of the
peritoneum showed only a patchy deposit of fibrin with a rare
polymorphonuclear cell.
C. MISCELLANEOUS LESIONS
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