The pathology of influenzaWinternitz, M. C. (Milton C.)
Science
The pathology of influenza
Winternitz, M. C. (Milton C.)
Influenza
162. Wolbach, S. B.: Comments on the Pathology and Bacteriology of
Fatal Influenza Cases Observed at Camp Devens, Massachusetts;—Bull.
Johns Hopk. Hosp., 1919, 30, 104.
163. Wollstein, Martha: An Immunological Study of Bacillus
influenzæ;—J. Exp. Med., 1915, 22, 445.
164. Wollstein and Goldbloom: Epidemic Influenza in Infants;—Am. J.
Dis. Children, 1919, 17, 165.
165. Woolston and Conley: Epidemic Pneumonia (Spanish Influenza) in
Pregnancy;—J. A. M. A., 1918, 71, 1898.
166. Yanagisawa: Experimental Study on the Mixed Injection of Bacillus
influenzæ and Various Species of Cocci;—Kitasato Arch. Exp. Med.,
1919, 3, 85.
[Illustration:
FIG. LV. AUTOPSY NO. 146. ACUTE HEMORRHAGIC ENTERITIS ASSOCIATED WITH
MULTIPLE BACTERIAL EMBOLI IN THE CAPILLARIES OF THE INTESTINAL
MUCOSA.
]
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Footnote 1:
The history of the epidemics of influenza cannot but impress one with
the difficulties of medical progress. Beyond the fact that the
descriptions of the epidemics are such that the disease is
recognizable as being the same, there is little of real value in the
literature until the beginning of the 19th century.
In the 18th century the infectious nature of the malady had been
recognized. The results of study in the first half of the 19th century
are shown in the literature of the epidemic of 1847–49. In it,
exceptionally good clinical descriptions and epidemilogical studies
are published. In the next forty years great strides were made in
Pathology and in the essentially new science of Bacteriology. With
those two aids in the study of infectious disease, it is only
reasonable to expect an increase in knowledge of influenza after the
epidemic of 1889–90. Such is the fact and a comprehensive review of
both the Bacteriology and Pathology of this disease is offered in
Nothnagel’s Specielle Pathologie, 1896, Bd. IV, by O. Leichtenstern.
Footnote 2:
Early in the epidemic, Nicolle (106) and his co-workers described a
filterable virus as the probable etiological agent in influenza.
Several investigators have corroborated this work. Chief of these are:
Gibson, Bowman, and Connor (46); Bradford, Bashford, and Wilson (16).
The latter investigators independently isolated a filterable virus
which may be cultivated by the Noguchi method and which, when
inoculated into monkeys, produces a general reaction with specific
respiratory lesions which, they think, are comparable to those of man
in influenza. While these results must be confirmed, they offer
greater promise than any other.
Footnote 3:
Public-domain text, read in full here on John Shaqi.
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