The pathology of influenzaWinternitz, M. C. (Milton C.)
Science
The pathology of influenza
Winternitz, M. C. (Milton C.)
Influenza
A marked fibrinous exudate in the lower trachea with the formation of
a pseudomembrane was noted by Oberndorfer (108), Lubarsch (19), Coray
(28), Borst (15), and Schmorl (128). Schmorl studied the bacteria from
the trachea and found in sections streptococci, pneumococci, and
staphylococci, but not B. influenzæ or B. diphtheriæ.
Footnote 4:
Simmonds (131), Bernhardt and Meyer (19) note that perichondritis may
be present, but do not give a detailed description of the lesion.
Gruber and Schädel (50) found this perichondritis to be associated
with abscess formation.
Footnote 5:
Two examples of fresh endocarditis are reported by Malloch (95) and
one by Dietrich (34), all of which were due to B. influenzæ. Acute
myocarditis was observed by Blanton and Irons (12) and Gruber and
Schädel (50). Glaus and Fritzsche (47) report a case with multiple
hemorrhages, necrosis, and leucocytic infiltration of the heart muscle
and also one of Zenker’s degeneration of the myocardium. Cases of both
myocarditis and endocarditis are included by Leichtenstern (82) in a
review of the epidemic of 1889–1890.
Footnote 6:
The picture is not unlike that of the interstitial pneumonia after
measles as described by MacCallum (93).
Footnote 7:
Pneumothorax as a complication following influenzal pneumonia is
mentioned in association with marked emphysema in the epidemic of
1889–90 by Leichtenstern (82). It has been found by X-ray examination
in two cases of interstitial emphysema by Berkley and Coffen (8) and
also has occurred at Camp Dix according to the report of Synnot and
Clark (143).
Footnote 8:
The rarity of empyema has been commented upon by LeCount (78) and
Torry and Grosch (149). The condition was found in a small number of
cases by Wegelin (156), Malloch (95), Lyon (90), Chickering (25), and
Thomas (146), while Goodpasture (48) described it in eleven out of
sixteen cases of streptococcus hemolyticus pneumonia.
Footnote 9:
Fibrinopurulent pericarditis has been described by Simmonds (131),
Stone and Swift (138), Lyon (90), Fildes et al (40), Jaffé (66), Glaus
and Fritzsche (47).
Footnote 10:
The types of consolidation described as having been encountered at the
post-mortem table apparently vary somewhat with the locality and the
interpretation of the observers. The lobar type has been frequently
found by Opie et al (110), Wollstein and Goldbloom (164), Stone and
Swift (138), and others. The pseudolobar pneumonia has been mentioned
by Abrahams et al (2), Keegan (67), and Speares (135), while the
peribronchial type has been well described by Hubschman, Glaus and
Fritzsche (47), and MacCallum (92). Lobular pneumonia has been noted
by all observers. The type of consolidation in this series has been
tabulated in relation to the inflammatory reaction.
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