_Circulation_: in the frog a marked effect on heart-beat: diminished rapidity, but increased duration; in the dog a small dose causes a slight rise in pressure, stronger doses considerable depression on the heart and vasodilation; in the cat mescaline causes initial lower pressure, slowly rising, and with a larger dose a greater initial fall, more marked slowing in beat, with variable promptness in recovery. In man .05 gr. of lophophorine causes marked slowing of beat but a rise in pressure and force. An ordinary dose of four “buttons” produces a 15-25% fall in the number of beats, with a slow recovery from a sharp drop unless more are eaten. But death in guinea pigs and frogs comes through paralysis of respiration, not of the heart, since in Wiley’s experiments it would beat 15-20 minutes after the death of the animal. “All this evidence points to the conclusion that the main effect of these alkaloids is a direct one on cardiac muscle ... [since] very large doses, quite non-therapeutic in amount, are ... required before the colour visions ... are observed.” _Salivation_: increased in the cat, whether administered by mouth or subcutaneously; the alkaloids are secreted in the saliva (one cc. of cat saliva produces the same symptoms in a frog); in man salivation is somewhat increased. _Digestive system_: in small doses pan-peyotl is constipating, according to some. In the cat large doses produce diarrhea and blood in the feces. In man and the quadrupeds all sensations of hunger are suppressed or absent during the period of intoxication, but the appetite returns somewhat increased after recovery; on first injection or ingestion there is a marked nausea and feeling of fullness in the stomach which passes off, without, however, hunger arising. _Blood, secretions, etc._: no increase in the coagulability of the blood; pancreatic and biliary secretions unaffected. _Kidneys_: peyote alkaloids chiefly excreted by the kidneys; experiments show increased renal blood supply, and pan-peyotl is markedly diuretic. _Eyes_: in the later stages of intoxication the pupils are widely dilated, accompanied by lack of accommodation and consequent photophobia.