_Nervous system_: sizeable doses produce their most marked effect on the nervous system: wakefulness (despite cardiac and muscular depression), exaggeration of all reflexes (due to selective action on the spinal cord). A frog injected with pan-peyotl became “exceedingly susceptible to stimuli, until even the slightest touch or even a breath of cold air is sufficient to give rise to a little nervous explosion, with the resulting contraction of several muscles”; the frog became rigid in tetanus as the reflexes degenerated. Convulsions are produced in the dog with ⅕ cc. of pan-peyotl, sometimes light, sometimes as violent as those of strychnine; death in convulsions with 1 cc. per kilogram of body weight. Pan-peyotl immediately kills a rabbit with a dose of 2 cc. per kilogram of body weight, injected intravenously; 2 cc. injected in the lymphatic sac paralyzes a frog. An injected cat shows “ataxic gait, with jerky and stiff movements”—a staccato effect in an animal notable for the legato quality of its movements—with “irregular twitchings of muscles over the whole body.” The same effects, less marked because of relatively smaller doses, appear in man as in other mammals. Extraordinary doses cause qualitatively and quantitatively the same reactions: the writer has seen a child, quite ill and suffering from malnutrition, brought very fretful into a peyote meeting and fed peyote “tea” until rigid in strychnine-like tetanic opisthotonos.