That year, on the fourth of October, occurred the dangerous uprising of twenty thousand Chinese, who lived in the environs of Manila. Although they were conquered and punished after two months of war, it was at a great loss to the country and to the Spaniards. In the first onset one hundred and fifty of the best Spaniards were killed, almost all citizens, although there were not more than seven hundred citizens. The island was desolated and destroyed for more than twenty leguas round about the city, which was in danger of being lost. The inhabitants who were left had to sally out, and, pursuing the enemy, finally conquered and made an end of them. That year, of the two ships that sailed according to the permission, die flagship "Nuestra Señora de los Remedios," after having cast out a great part of its cargo, and having lost its masts, put in at Manila; while the "San Antonio," most richly laden, and with many people who, in order to escape the hardships of that city, were going to Nueva España, suffered a greater hardship--for it was swallowed up by the sea, and no one heard what became of it. In the year 604 was despatched the general decree granting the permission to the islands, which restricted the commerce with Nueva España, as has been declared. In the year 606, Governor Don Pedro de Acuña made the Maluco expedition, which, although it had a good outcome, was very costly for the citizens of Manila, most of whom took part in it. He took five galleons, four galleys with poop-lanterns, three galliots, four champans, three fustas, two lanchas, two brigantines, one flat-bottomed boat, and thirteen fragatas with high freeboard. He had one thousand three hundred Spaniards serving for pay, besides the volunteers and inhabitants, who were numerous. All incurred the expense that can be imagined in the expedition, without deriving other advantage than their service as loyal vassals. That year, while the governor was in Maluco with all the force of the islands, the Japanese revolted in Manila, and the country arose in arms and was in great danger; but, after they had done some damage and caused much, they were subdued. In the year 608, two ships sailed for Acapulco, under command of Juan Tello de Aguirre, and the flagship was wrecked in the Embocadero of Capul, one hundred leguas from Manila. In the year 609, three ships sailed under command of Juan Ezquerra. The flagship "San Francisco" was wrecked in Japon, and the ship "Santa Ana," which went to Nueva España the following year, put in at the same island. In the year 610, of the two ships that sailed in accordance with the permission, the almiranta returned to put in at Filipinas.