18. This concrete substance, fibrous or laminated, is variously modified either alone or in combination with the rounded particles. These different modifications and combinations constitute different kinds of organic substance. When so distinct as obviously to possess a peculiar structure and peculiar properties, each of these modifications is considered as a separate form of organized matter, and is called a PRIMARY TISSUE. Anatomists and physiologists have been at great pains to discriminate and classify these primary tissues; for it is found that when employed in the composition of the body, each preserves its peculiar structure and properties wherever placed, however combined, and to whatever purpose applied, undergoing only such modification as its local connexions and specific uses render indispensable. Considering every substance employed in the construction of the body, not very obviously alike, as a distinct form of organized matter, these primary tissues may be said to consist of five, namely, the membranous, the cartilaginous, the osseous, the muscular, and the nervous. 19. The first primary tissue is the peculiar substance termed MEMBRANE. It has been already stated (16) that one of the ultimate forms of animal matter is a coagulable substance, becoming concrete or solid under the process of coagulation. The commencement of organization seems to be the arrangement of this concrete matter into straight thready lines, at first so small as to be imperceptible to the naked eye. Vast numbers of these threads successively uniting, at length form a single thread of sufficient magnitude to be visible, but still smaller than the finest thread of the silkworm. If the length of these threads be greater than their breadth, they are called fibres; if, on the contrary, their breadth exceed their length, they are termed plates or laminæ. By the approximation of these fibres or plates in every possible direction, and by their accumulation, combination, and condensation, is constituted the simplest form of organized substance, the primary tissue called membrane.