In a memoir published in 1842, John Goodsir advocated the view that the nucleus is the reproductive organ of the cell, and that from it, as from a germinal spot, new cells were formed. In a paper, published three years later, on nutritive centers, he described cells, the nuclei of which were the permanent source of successive broods of young cells, which from time to time occupied the cavity of the parent cell. He extended also his observations on the endogenous formation of cells to the cartilage cells in the process of inflammation and to other tissues undergoing pathological changes. Corroborative observations on endogenous formation were also given by his brother, Harry Goodsir, in 1845. These observations on the part which the nucleus plays by cleavage in the formation of young cells by endogenous development from a parent center--that an organic continuity existed between a mother cell and its descendants through the nucleus--constituted a great step in advance of the views entertained by Schleiden and Schwann, and showed that Barry and the Goodsirs had a deeper insight into the nature and functions of cells than was possessed by most of their contemporaries, and are of the highest importance when viewed in the light of recent observations. In 1841 Robert Remak published an account of the presence of two nuclei in the blood corpuscles of the chick and the pig, which he regarded as evidence of the production of new corpuscles by division of the nucleus within a parent cell; but it was not until some years afterwards (1850 to 1855) that he recorded additional observations and recognized that division of the nucleus was the starting-point for the multiplication of cells in the ovum and in the tissues generally. Remak’s view was that the process of cell division began with the cleavage of the nucleolus, followed by that of the nucleus, and that again by cleavage of the body of the cell and its membrane. Kölliker had previously, in 1843, described the multiplication of nuclei in the ova of parasitic worms, and drew the inference that in the formation of young cells within the egg the nucleus underwent cleavage, and that each of its divisions entered into the formation of a new cell. By these observations, and by others subsequently made, it became obvious that the multiplication of animal cells, either by division of the nucleus within the cell, or by the budding off of a part of the protoplasm of the cell, was to be regarded as a widely spread and probably a universal process, and that each new cell arose from a parent cell.