The salt mixture mentioned above increases the solvent power of the water for mucus, pus, and other collected material and it also renders the water less irritating to the mucous membranes. Other than this, it has no value so far as I know. This solution is certainly not antiseptic or germicidal, further than that cleanliness may be considered an antiseptic procedure. The phenol-glycerine (10% phenol and 90% glycerine) which we have recommended, is somewhat germicidal, non-irritating, except to the nasal mucosa, is a protectant to inflamed membranes in some instances and is also somewhat hygroscopic. These virtues to the limited extent that they may be of advantage, depend chiefly upon physical qualities. Adrenalin in high dilutions (1 to 5000 to 1 to 10,000) is of value in retracting the erectile tissues of the nares for purposes of examination and for obtaining better drainage, etc. It also constricts the small blood vessels and thus reduces the chances for hemorrhage or absorption of narcotic drugs which may necessarily be used as local anesthetics. The effects of adrenalin are very temporary and it is, therefore, of little value in treatment. Following irrigation I have used the petroleum oils (liquid petrolatum) to advantage as a protection to the mucous membrane. One-half gram each of menthol and camphor and two or three drops of cinnamon oil to the pint of this oil, is readily dissolved and produces a pleasant, soothing effect to inflamed membranes, but further than this, the added substances have no particular value. The above named chemical agents constitute, except in rare instances, my stock of “drugs” for treatment purposes. Hyperesthetic Rhinitis—Hay Fever There is perhaps no disease in which there has been more speculation concerning the etiology than in hay fever, and while osteopathy has accomplished a wonderful advance in the treatment of this disease, I am not sure that the cause or causes are yet thoroughly understood. =Etiology.=—The theoretic causes of this disease may be expressed in the various names which have been given to it as follows: The term Hay Fever suggests that it is a febrile condition caused by hay pollen irritation. Peach cold, Rose cold, Rose fever, Rose catarrh, Rye fever and Ragweed fever suggest similar specific causes. Idiosyncratic coryza means nothing and this probably expresses what the theorists know about its cause better than any other name. Hysteric rhinitis suggests a probable psychic cause, which certainly does exist in some cases. If I may be pardoned, and I know I never will be, let me suggest just one more name—“Respiratory Reflex Inefficiency.” =Intoxications.=—Auto-intoxication from focal infections or from gastro-intestinal perversions certainly have an important influence either directly or as predisposing factors and should always be carefully considered in treatment.