Auto-intoxication from some gastro-intestinal affection is commonly a cause and must receive proper attention. The general health of the patient must be restored and maintained. Thorough osteopathic treatment must be given for any cause of lowered nutrition, local or general. The failure, I believe, in medical practice (They admit failure in this disease) is due to the lack of attention to the restoration of normal nutrition. Why drain a sinus and leave an atlas or upper thoracic lesion which decreases the local nutrition and leaves these membranes susceptible to further infection? Before and after surgical drainage, irrigation of the nasopharyngeal tract. Thorough irrigation to cleanse every part. Hot irrigation (one gallon of salt mixture solution, salt 3 parts, borax 2 parts, and soda 1 part, a tablespoonful to the gallon at 118°F. to 123°F.) to cleanse, to free all parts from infection and to restore blood supply to the affected parts. Frequent irrigation, daily for a sufficient time to thoroughly sterilize and restore circulation. After each irrigation, an oil spray (any non-irritating petroleum oil) is applied freely to protect the membranes from irritation and further infection. Before each irrigation a thorough probe treatment, as described under hypertrophic rhinitis, should be given that the membranes may be thoroughly freed from all retained secretions. After the membranes are once clean, the sinuses free from infection and the blood supply reestablished, the treatment may be reduced in frequency to three times weekly, but the treatment must be continued for months or even years to effect a permanent cure. The patient can be taught to do his own irrigation after the disease is well under control. All irritating sprays, chemical cauteries, etc. must be avoided. The so-called “antiseptic sprays” do harm by irritating the membranes and certainly do no good, because they do not cleanse the parts. They only serve to deodorize, but actually accomplish nothing in the way of cure. It has been my experience that iodine and the silver salts in any of their various preparations are not efficient but that they actually do harm. My experience indicates that practically every case can be cured if the proper treatment is given for sufficient time. Pharmacodynamics If I may be pardoned for discussing things pharmacological in a text on practice, I want to urge that chemicals as such, are usually a failure in treatment. My results from various series of experimental work both laboratory and clinical, show quite conclusively that there are very few, if any, chemical substances that have actual value by virtue of their chemical properties alone. There are, however, cases in which chemical agents may be used to advantage to obtain desirable physical results and physiologic reactions.