=Treatment.=--If any case can be imagined in which efficient treatment is most urgently demanded it is one of tetanus. In scarcely any disease, however, is drug treatment so unsatisfactory. In the rare instances in which patients have recovered it is questionable whether it is not due to individual resistance rather than to medication. Treatment may be subdivided into _local_, _constitutional_, and _specific_. If there is still an _open suppurating or discharging wound_, it is, of course, essential to cleanse this out, basing this advice in some measure upon general principles--largely upon the fact, already stated, that ordinarily only the immediate surroundings of such a wound are found infected by the bacilli themselves. Consequently thorough _scraping_, _excising_, and _cauterization_, either with powerful caustics or the actual cautery, are indicated. Since the specific germ is an anaërobe, hydrogen dioxide may be used locally with great advantage, mainly because it oxidizes the albuminous material upon which the bacilli thrive. If it is in a finger or toe, amputation may be the simplest method of eradicating the local lesions. _Constitutional treatment_ may be divided into _nutrition_ and medication. The tendency too often in these cases is to be careless or indefinite with regard to the excretions and the nutrition of the patient. If, for instance, each attempt at catheterization throws him into convulsions, the bladder may become overdistended and burst. So, too, there is apprehension usually in regard to fecal evacuations. At the same time these patients are allowed to almost starve because of the difficulty of feeding them. It is advisable to resort to chloroform to permit the introduction of the stomach tube--through the nostrils, if necessary--by which nutrition may be introduced into the stomach without causing the violent convulsions that would occur without an anesthetic. At the same time the catheter may be used. In the way of _active medication_ there is no agent so efficacious for controlling the tetanic spasms as _chloroform_, which may be administered occasionally, or more or less continuously, according to the wishes of the attendant. By its use the severest spasms can be kept in abeyance, and the horrible character of the disease somewhat mitigated. Of the other medicaments used, most of them are of the nature of nerve sedatives, such as _chloral_, the _bromides_, _Calabar bean_, _cannabis indica_, _opium_, etc. Hot-air baths or diaphoretics, by which copious perspiration may be induced, have yielded good results. _Specific treatment_ means in these instances taking advantage of the well-known properties which the _blood serum of an animal artificially immunized_ against the disease possesses. This is in accordance with experimental labors with a number of different diseases, of which tetanus is one. It is, in effect, similar to the serum therapy of diphtheria.