The principles and practice of modern surgeryPark, Roswell
Science
The principles and practice of modern surgery
Park, Roswell
Surgery
=Phagocytosis.=--All leukocytes have the power of shifting their
location. The lymphocytes, so called, being the youngest of the white
corpuscles, show it less than the older forms. The eosinophile cells
are less able to manifest the peculiar activities of the other forms.
It is particularly the mononuclear and polynuclear corpuscles which
are endowed with most pronounced activity. These have the power,
like the ameba among the lowest forms of life, to not only spread
themselves around inert bodies, like granules of carmine or other
particles used for experiment, or the particles of coal-dust found in
certain conditions in the human body, but they also have the power to
englobe many living organisms, for the main part vegetable (bacteria).
Under the microscope it is possible to see living bacilli, performing
active movements, although enclosed in the nutritive vacuoles of
the leukocytes, in some of the lower animals. This _ameboid_ power
possessed by these cells of thus attacking and disposing of foreign
bodies or irritants has been demonstrated and proved, especially by
Metchnikoff, and has been called by him _phagocytosis_. His views
were for a long time disputed, and are perhaps not yet absolutely and
generally accepted. Nevertheless, they fulfil every demand made upon
them for explanation, and are susceptible of such demonstration under
the microscope that we now have practically a new and apparently a
correct theory of the inflammatory process. (See Chapter III.) Any
cell which has this property is known as a _phagocyte_. It is shared
by some of the leukocytes with certain other cells to be spoken of
later (wandering tissue cells). Cells which possess this power do not
attract all microbes indiscriminately, and it is often the case that
the leukocytes of an animal peculiarly susceptible to a certain kind
of bacteria do not attract them at all, even though they are directly
in contact. It is plausible that an explanation of the peculiar
susceptibility of certain animals to certain diseases is furnished by
this fact (Fig. 3).
[Illustration: FIG. 3
Phagocytosis in anthrax pustule. (Gaylord.)]
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