which carry on active functions are nitrogenous; while parts that are non-nitrogenous--as the deposits of fat--carry on no active functions. And we even find that the appearance of non-nitrogenous matter throughout tissues normally composed almost wholly of nitrogenous matter, is accompanied by loss of activity: what is called fatty degeneration being the concomitant of failing vitality. One more fact, which serves to make still clearer the meaning of the foregoing ones, remains--the fact, namely, that in no part of any organism where vital changes are going on, is nitrogenous matter wholly absent. It is common to speak of plants--or at least all parts of plants but the seeds--as non-nitrogenous. But they are only relatively so; not absolutely. The quantity of albumenoid substance in the tissues of plants, is extremely small compared with the quantity contained in the tissues of animals; but all plant-tissues which are discharging active functions have some albumenoid substance. In every living vegetal cell there is a certain part that includes nitrogen as a component. This part initiates those changes which constitute the development of the cell. And if it cannot be said that it is the worker of all subsequent changes undergone by the cell, it nevertheless continues to be the part in which the independent activity is most marked. Looking at the evidence thus brought together, do we not get an insight into the actions of nitrogenous matter as a worker of organic changes? We see that nitrogenous compounds in general are extremely prone to decompose: their decomposition often involving a sudden and great evolution of energy. We see that the substances classed as ferments, which, during their own molecular changes, set up molecular changes in the accompanying carbo-hydrates, are all nitrogenous. We see that among classes of organisms, and among the parts of each organism, there is a relation between the amount of nitrogenous matter present and the amount of independent activity. And we see that even in organisms and parts of organisms where the activity is least, such changes as do take place are initiated by a substance containing nitrogen. Does it not seem probable, then, that these extremely unstable compounds have everywhere the effect of communicating to the less unstable compounds associated with them, molecular movements towards a stable state, like those they are themselves undergoing? The changes which we thus suppose nitrogenous matter to produce in the body, are clearly analogous to those which we see it produce out of the body. Out of the body, certain carbo-hydrates in continued contact with nitrogenous matter, are transformed into carbonic acid and alcohol, and unless prevented the alcohol is transformed into acetic acid: the substances formed being thus more highly oxidized and more stable than the substances destroyed. In the body, these same carbo-hydrates, in continued