On the clinical side the reports are not numerous and such as have been made do not appear to be based on very extensive trials nor on conditions of observation that would entitle them to more than slight consideration. S. D. Bullington[64] reports good results, but no cure, in one case of epilepsy, and improvement in a case of insomnia. W. J. Stapleton[65] recommends it in the form of a concentrated tincture (not the one advertised so extensively), and states that he has used it with great success in insomnia, hysteria, neurasthenia, neuralgia, nervous and physical prostration, and in alcoholism. In his opinion its action is most apparent in cases of nervousness due to causes other than pain. S. Harnsberger[66] reports two cases in which partial blindness followed the taking of potassium bromid and passion flower. [64] Nashville Jour. Med. and Surg., 1897, lxxxi, 107-109. [65] Detroit Med. Jour., 1904-5, lv, 17. [66] Virginia Med. Semimonthly, 1898-9, iii, 392. Extravagant and inconsistent claims are made for Daniel’s concentrated tincture of passiflora in the advertising literature, where it is recommended for such a wide range of diseases as asthma, typhoid fever, convulsions and paralysis. None of the evidence is sufficient to show that passiflora has therapeutic value; hence it is deemed inadvisable to include this drug in the list of nonofficial remedies.--(_From The Journal A. M. A., March 19, 1910._) LIQUID COMBINATIONS CONTAINING PEPSIN AND PANCREATIN[AH] Report of the Council on Pharmacy and Chemistry of the American Medical Association [AH] See also Reexamination of Lactopeptine, p. 121. A reprint of articles bearing on this subject is issued under the title Digestive impossibilities. The following report was submitted to the Council by a subcommittee: _To the Council on Pharmacy and Chemistry_:--The U. S. Pharmacopeia, 8th revision, pages 334-5, states: “Pepsin and pancreatin in solution are incompatible with one another. If the solution be neutral or alkaline the pancreatin gradually destroys the pepsin, and if acid the pepsin destroys the pancreatin.” The correctness of this statement has been amply demonstrated by the reports which have been submitted to the Council from time to time on liquid preparations claimed to contain these two ferments. Thus an elixir was investigated which was by the manufacturers claimed to contain “the five active agents of digestion, pepsin, veg. ptyalin, pancreatin, lactic and hydrochloric acids,” and to be “superior to all other remedies in dyspepsia and diseases arising from imperfect digestion,” and the committee which investigated the article in question reported that “it was impossible to establish the presence of either the proteolytic or the amylolytic ferment.”