The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
Similarly, on another liquid preparation, which was said to
contain “pancreatin, pepsin, lactic and muriatic acids, etc.” ...
“the combined principles of digestion to aid in digesting animal
and vegetable cooked food, fatty and amylaceous substances,”
the committee reported “this product possessed only very slight
proteolytic action and failed to digest 2 per cent. of its own weight
of starch.”
Again, the report on still another preparation stated: “But while it
was said to contain pancreatin, the U. S. P. test for the valuation
of pancreatin failed to indicate this ferment.”
The report on yet another elixir, claimed to be “the only true
digestant, because it contains the enzymes of all the glands which
are necessary for digestion,” showed that this article did not
contain “any appreciable enzyme activity, either amylolytic or
proteolytic.”
The correctness of these findings of the committee of the Council was
generally acknowledged by the manufacturers when their attention was
called to the matter. Thus, one manufacturer of digestive ferments
writes: “We will ask you to hold this matter up until you hear from
us further on the subject. The reason for this request is that we
have been going over our liquid preparations very carefully in order
to be sure that after aging they would contain the ferments that we
put into them. The pancreatic ferments in alcoholic liquids seem to
lose their strength.”
The chemist for a large manufacturing house writes: “There are now on
the market a number of preparations in which pepsin and pancreatin
are combined in liquid form, and the result is that we have had
numberless requisitions from our representatives that we also market
such a preparation. As the result of this we have carried out a
series of experiments no less than four or five times in order to
determine whether pepsin, diastase, and pancreatin would retain their
activity in the form of a syrup, wine or elixir. We have proved
incontrovertibly that this cannot be done. While any two of these
substances, or even all three of them, can be dispensed in the form
of a liquid by the retail druggist and will retain their normal
activity for as long a period as three to six weeks, yet if allowed
to stand sufficiently long, they mutually destroy each other; so that
in a combination of pancreatin and pepsin the pancreatic enzyme is
lost and the pepsin greatly injured, and where diastase is present,
both diastase and pepsin (or diastase and pancreatin) mutually
destroy each other.”
Since it has been demonstrated that pepsin and pancreatin cannot
exist in one and the same solution for any reasonable length of
time, it becomes apparent that liquid preparations said to contain
these two ferments are sold under impossible claims. It is therefore
recommended:
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