The proof that the absence of secretin is characteristic of diabetes or of marasmus is not yet available. Sweet and Pemberton[81] found that many circumstances interfered with the extraction of secretin, so that the mere failure to obtain it in a given case is not proof of its absence, unless the various inhibiting influences are given due consideration. The conclusions reached by these authors are that “the evidence so far adduced that secretin is absent in some varieties (of diabetes) does not seem conclusive,” and that “the specific absence or deficiency of secretin in marasmus seems to remain as yet unproven.” [81] Sweet, J. E., and Pemberton, R.: Experimental Observations on Secretin, Arch. Int. Med., February, 1908, p. 231. The favorable reports of Moore[82] in regard to the use of secretin in diabetes are not confirmed by the experience of Foster[83] in five cases, or by the case reported by Dakin and Ransom.[84] [82] Moore, Edie and Abram: Biochem. Jour., 1906, i, 28; ibid., i, 446. [83] Foster, N. B.: Cases of Diabetes Treated with Secretin, Jour. Biol. Chem., January, 1907. [84] Dakin, H. D., and Ransom, C. C.: Treatment of Case of Diabetes with Secretin, Jour. Biol. Chem., January, 1907. In regard to the use of secretin in intestinal disorders, the G. W. Carnrick Company refers to an article by J. W. Beveridge.[85] An examination of this article shows it to be unscientific and uncritical. The author presents four cases to “demonstrate the peculiar potency exercised by secretin.” Of the first he says: [85] Beveridge, J. Wallace: Secretin, Am. Jour. Gastro-Enterology, April, 1914, p. 170. “Stomach was dilated, food delay, seventy-two hours; hyperacidity, vomiting daily, five to twelve times, urine high specific gravity, over 3 per cent. urea, trace albumen.” The patient improved somewhat after gastro-enterostomy with removal of the gallbladder; the vomiting ceased, but the stools continued clay-colored and the high urea output still kept up. Secretin was given, and after this the report continues: “The stools became normal in color at the end of the second month, weight gradually increased until 122-3/4 pounds was reached, and the urea is now normal, averaging about 1 per cent.”