“In malarial conditions there is nothing that acts so promptly and efficaciously as Sinkina. Sinkina destroys radically every trace of the parasite in the blood from the time of its first appearance, builds up the damaged corpuscles, revitalizes the system, and completely eliminates every trace of the disease. Sinkina is deservedly termed the _Specific_ for Malaria.” These claims were supported by testimonials which usually gave no indication of a demonstration of the presence or absence of malarial plasmodia in the blood. The following is an example showing the character of most of the evidence presented by the manufacturers: “Three weeks ago I prescribed Sinkina for a negro man 40 years of age suffering from a double tertian malarial infection having a chill every afternoon for four consecutive days. He came to my office about 8 a. m. and was due to have a chill about 6 p. m. I gave him the sample of Sinkina and directed him to take a tablespoonful at once, also at noon and again at 4 p. m., and to continue taking it in same size dose three times a day till he had taken it all. He reported to me in a week from that date and told me he was feeling fine and that he hadn’t had any more chills. The patient up to this time is apparently cured.” As the claims were supported by a few testimonials purporting to be based on exact investigations, the Council submitted the preparation to careful laboratory and clinical tests. For this investigation the Council was fortunate in securing the help of physicians actively engaged in the study of malaria. Experiments were made _in vitro_ with the preparation; 1 ounce of Sinkina was used, and its action was compared with that of 10 grains of quinin sulphate. When these were added to cultures of malarial plasmodia in proportion corresponding to 1 ounce of Sinkina or 10 grains of quinin sulphate for a 150-pound man, the quinin was found to be unfailingly antagonistic to the malarial organism, the drug prevented the segmentation of the organism, and finally killed it in about thirty-six hours. The Sinkina did not kill the parasite after seventy-two hours of continued action, and the parasites segmented in the presence of it just as actively as they did in the control.