The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
1. Since iodids are easily absorbed from the mucous membrane of the
gastro-intestinal tract and are usually well tolerated by the stomach,
there is no reason for resorting to intravenous injection in their
administration.
2. The indiscriminate administration of iodids for pulmonary
tuberculosis is strongly to be condemned. The cases in which they
can be given to tuberculous patients without doing harm must be very
carefully selected.
3. There is no evidence either that creosote is excreted by the lungs
in sufficient quantity to exert an anesthetic influence or that
iodin is present in the circulation of the lungs or in the bronchial
secretions in a form which is capable of exerting any germicidal action
whatever.
4. It is generally held that the systemic administration of iodin
compounds in bacteremias is useless.
The Council also held the name “Venodine” objectionable in that it
fails to indicate the chief ingredient (sodium iodid) of this simple
pharmaceutical mixture. The statement in a circular that “Venodine
is a sterile solution representing 1.54 Gm. (24 grains) of iodine in
chemical combination together with creosote and guaiacol” is likely
to lead physicians to use the preparation without considering that
its chief constituent is the well-known substance sodium iodid,
particularly so since no reference to sodium iodid is made in the
circular.
Furthermore, the Council held that the combination of two such similar
substances as creosote and guaiacol (the second a constituent of
the first) as given in the published formula, stamps Venodine as
unscientific; it adds mystery to the preparation, but does not increase
its efficiency, and is therefore against the best interests of the
public.
The Council voted that Venodine be held ineligible for conflict with
Rules 6, 8 and 10.
This report having been submitted to the manufacturers, in
accordance with the Council’s custom, and the reply affording no
reason for modifying the findings, its publication has now been
authorized.--(_From The Journal A. M. A., June 26, 1915._)
VERACOLATE[AM]
Report of the Council on Pharmacy and Chemistry
[AM] For report on a similar compound, see Taurocol, p. 198.
“Veracolate (plain),” “Veracolate with Pancreatin and Pepsin” and
“Veracolate with Iron, Quinine and Strychnine” are proprietary tablets
marketed by the Marcy Company, Boston.
“_Veracolate_ (_plain_).”--For this the following non-quantitative
formula is given:
“A compound containing the bile acids, sodium glycocholate, sodium
taurocholate with cascara sagrada and phenolphthalein.”
The dose is three tablets. Examination in the Chemical Laboratory of
the American Medical Association of a specimen of “Veracolate (plain)”
indicated that there was about 20 mg. (1/3 grain) of phenolphthalein to
each tablet. One dose, therefore (three tablets), would contain 1 grain
of phenolphthalein--an average dose.
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