First, however, we shall take this opportunity to publish some matter which we have had in reserve since the first exposé was made last October. When it was realized that Mr. Tyree intended to defend himself by claiming that a change had recently been made in the powder, we took occasion to try to secure some of the preparation that had been on the market for a long time. In this we succeeded very well. From a Chicago druggist one package was bought which had been in the store at least since July, 1902--how much longer is not known. The druggist from whom the powder was obtained bought the drug store in July, 1902, and this powder was on hand at that time, none having been bought since. This particular powder was analyzed by a chemist, who found the composition practically the same as that given in the Council’s report, this chemist estimating that it contained approximately 81 per cent. boric acid and 14 per cent. anhydrous zinc sulphate. Bearing in mind that for at least four years and ten months Tyree’s Powder has been essentially the same as it is today, this letter is very interesting: (The comments in brackets are, of course, ours.) “J. S. TYREE, “Chemist, “WASHINGTON, D. C. “April 16, 1907. “Dr. --------, “----, “_My Dear Sir_:--Doctors and medical publications of extreme and prejudicial minds often hold and express opinions in honorable faith, but like all critics, they are not always familiar with the conditions composing their opinions, and are often given to expressing them without knowledge of the true motives and facts in the case. “If you will read an article that appeared in one of the medical weeklies some time ago [The Journal of the American Medical Association, of course] and which has been copied by several of its offsprings [not many we regret to say] relating to Tyree’s Antiseptic Powder, you will see that I had previously informed the editor as well as his council of investigators, that at the suggestion of prominent physicians, extensive clinical experimenting [sic] were being made with some slight [! ! !] changes in my powder, the object being to develop and extend its usefulness in new lines [It had already been recommended for about everything[2]] and at the same time make it more acceptable to the general run of the profession. I also notified this editor that these investigations would not be completed until the first of the present year, after which time these slight [! ! !] changes in the formula of Tyree’s Powder would be announced. [It is now the middle of May; when and where were the changes announced?[3]]