“Large doses must be given if we expect to control the convulsions. We are to be guided by the frequency and the severity of the seizures, the saturation of the system by bromides and by the age of the patient. The rule is ‘large doses for long periods but with occasional periodic monthly or quarterly omissions.’ When we have succeeded in controlling the convulsions in so far as greatly diminishing the frequency and severity of the attacks we may then attempt to decrease the dose, but the results must be carefully watched. Increase in frequency of convulsive seizures is a sign that the bromides must again be pushed as before.” The best modern clinical teaching concerning the treatment of epilepsy is that bromids should be avoided except as a last resort. Bromids do not cure, and the amount necessary to control the convulsions may produce a degree of mental hebetude that is a greater evil than the disease itself. It is recommended that the preparation be held ineligible for admission to N. N. R., because of its conflict with Rules 1, 4, 6 and 10 of the Council, and that this report be published. CHIONIA Chionia, according to the statement of the Peacock Chemical Company, which exploits the product, contains 19 per cent. alcohol and is “A Preparation of Chionanthus Virginica.”[4] [4] Of Chionanthus Virginica or fringe-tree, the Council on Pharmacy and Chemistry in its 1912 report on “Some Unimportant Drugs” said: “The drug is much used by eclectics and homeopathists, especially as a depurant in hepatic and syphilitic disorders.... The claims for this remedy are not supported by experimental evidence and clinical reports of its use fail to show indications of discriminating critical observation. It is not noticed by most pharmacologic authorities.” This preparation is advertised particularly as “a potent hepatic stimulant” and special claims are made for it in various disturbances of the liver: “Chionia is very well adapted in the treatment of hepatic congestion owing to its specific action in depleting the portal circulation.” In passive congestion of the liver, the manufacturers would have us believe “... we have a drug in Chionia that will stimulate the circulation of the blood and lymphatics of the liver as well as stimulate its physiological activities and instead of the patient vomiting the blood an internal depletion of the liver occurs.” “... in cases of simple jaundice due to circulatory (congestive) changes in the liver, Chionia is the drug ‘par excellence’ that will rapidly cause a disappearance of this symptom.” As a prophylactic against eclampsia, if a history of torpidity of the liver is obtained: “CHIONIA should be used during the major portion of child-bearing period because it acts directly on the liver stimulating its functional activity.”