The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
The reference to the work of Sherman is made because, in a following
paper in the same journal, he recommends the use of salt as an
activator in finding the strength of certain diastase preparations.
It is well known that dialyzed diastase preparations and starch of
highest purity have but slight action on each other; a little salt
increases the activity greatly, and also increases the activity of
commercial diastase preparations. These facts Sherman utilizes in
working out a method for valuation of commercial diastases. The facts
were well known to us at the time of our former report, but it was
not thought best to depart from the general method which had been
in use by all analysts following the general scheme of Roberts.
Quite recently, I. Bang has published a paper on the investigation
of diastase (_Biochem. Ztschr._, xxxii, 417) in which he studies the
behavior of sodium chlorid and other salts on the rapidity of starch
conversion, and finds that a much smaller amount of salt than Sherman
recommends brings the maximum increase.
The method employed in our former tests is a good comparative method,
and this is all that may be claimed at present for any method. By
adding salt to our starch solution the activity of Panase and other
ferments is likewise greatly increased. For Panase, a preparation
possessing rather high starch-converting power, we have recently
found an increase of about 30 per cent. in the converting power,
with salt present. Working to loss of blue color, merely, it is
possible in this way to get a higher value than that claimed by the
manufacturer. There is no practical gain in using the salt for our
purpose as the methods are at best arbitrary, and the results only
comparative.
Taking all the facts into consideration, it is recommended that the
rejection of Taka-Diastase and Liquid Taka-Diastase be allowed to
stand and that, in view of their extensive exploitation, this report
be authorized for publication so that physicians may know the facts.
This report was referred to Parke, Davis & Co., and they made the
following reply:
“The report submitted in your letter of the 23d is, we contend,
erroneous and unjust: first, to our Liquid Taka-Diastase, because
over three years ago we changed our formula, reducing the alcohol
from 18 per cent. to 10 per cent., increasing the glycerin and thus
prolonging greatly the period of activity.
Public-domain text, read in full here on John Shaqi.
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