The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
In the earlier tests 16 parts of starch converted by 1 part of the
ferment was the value found. These results are in close agreement
with values reported by Sherman (_Jour. Am. Chem. Soc._, xxxii, 1073)
for a sample of recent purchase. He found a conversion of 51 parts of
starch to the colorless end-point in _thirty_ minutes for one sample,
while for another he found 66 parts, in the same time. It will be
noted that our time limit is _ten_ minutes. It is worthy of note
that for a perfectly fresh and specially prepared sample furnished
by Dr. Takamine, a conversion of 278 parts in _thirty_ minutes was
found by Sherman. Taking the time into consideration, it will be seen
that the results are about the same for the market samples as those
found by us and much lower than claimed, as well as much lower than
for other makes of similar products. The difference in the behavior
of fresh specially prepared Taka-Diastase and the market sample is
very clearly shown. No one questions the fact that fresh laboratory
samples of Taka-Diastase may show a moderate converting power on
starch. But we have to deal with the _activity of market samples
only_, and Sherman’s work and our own show the low digesting power of
the product as physicians may secure it on the market.
The marked difference in activity between perfectly fresh and
ordinary market samples of Taka-Diastase is very clearly shown also
in a recent paper published by Wohlgemuth.[24] In the digestion
of starch paste to the “dextrin” stage Wohlgemuth found in the
commercial sample a strength approximately a hundred times less than
that observed in a fresh sample sent him by Dr. Takamine.
[24] Wohlgemuth: Biochem. Ztschr., March 18, 1912.
Wohlgemuth’s results were obtained by a method not essentially
different from ours, with this difference, however, that he digested
through 24 hours in the cases reported, and carried the reaction
to the “dextrin” stage only, in place of to a colorless end-point.
Making the proper reductions, it is evident that the actual values
found by him for the market samples bought in Germany are not greater
than those reported by us.
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