_Diabetes Mellitus._--Moore, Edie and Abram[64] were the first to suggest a therapeutic value for secretin, having obtained favorable results with secretin administration in diabetes. They argued that the internal secretion of the pancreas _may_ be stimulated by secretin, and that some cases of diabetes _may_ be due to lack of this necessary excitant. Owing to the importance of the question, their announcement was followed quickly by numerous investigations by other observers. Previously, Spriggs, at the suggestion of Starling, had tried intravenous injections of secretin free from depressor substance in a diabetic patient, and had obtained negative results. Moore, Edie and Abram gave their secretin by mouth over long periods. Of the five cases cited in their first paper, two were negative. The third was that of a man, aged 25, who received daily 30 c.c. of secretin. After a latent period of three weeks, the sugar suddenly fell, and after four months the urine was sugar-free. Six months later a relapse occurred with the development of phthisis and death. The other two patients were a boy, aged 7, and a girl, aged 9, whose urine in from three to five weeks became sugar free during the secretin treatment in spite of severe diabetes. One of these patients later relapsed.[65] Bainbridge and Beddard[66] gave secretin a thorough trial in three cases with negative results, and are disposed to attribute the results of Moore to dieting. Dakin and Ransom[67] cited one case, secretin being given for twelve weeks, with negative results; Foster,[65] nine cases, all negative; Charles,[68] three cases, all negative. Crofton,[69] however, gave secretin a trial in one case with favorable results. Moore, Edie and Abram, in a later paper,[70] report a large number of cases tried with the majority of results negative, though in some cases an improvement in the digestion, and in certain cases an increase of weight was noted. [64] Moore, Edie and Abram: Biochem. Jour., =1=:28, 1906. [65] Foster: Jour. Biol. Chem., =2=:297, 1906. [66] Bainbridge and Beddard: Biochem. Jour., =1=:429, 1906. [67] Dakin and Ransom: Jour. Biol. Chem., =2=:305, 1906. [68] Charles: Med. Press and Cir., =133=:578, 1906. [69] Crofton: Lancet, London, =176=:607, 1909. [70] Moore, Edie and Abram: Biochem Jour., =3=:82, 1908.