One method of testing the basis of Moore’s theory would be by examining the prosecretin content of the intestine in diabetics. Bainbridge and Beddard found, in the paper referred to,[66] that from five of the six cases of diabetics examined postmortem, little or no secretin could be prepared; but in a subsequent report of seven cases,[71] they found only one in which the secretin obtained was scanty. The failure to obtain secretin in some cases they claim is probably due to the rapid postmortem degeneration of diabetic tissue. Evans,[72] in Starling’s laboratory, found that in dogs made recently diabetic by total pancreatectomy, but little secretin could be obtained. Hedon and Lisbonne,[73] and Pemberton and Sweet[74] report, on the contrary, that the duodenum of diabetic dogs is rich in prosecretin. Bainbridge and Beddard,[71] working on a diabetic cat, likewise found prosecretin to be present in normal quantity. [71] Bainbridge and Beddard: Biochem. Jour. =3=:82, 1908. [72] Evan: Jour. Physiol. =44=:461, 1912. [73] Hedon: Compt. rend. Soc. de biol. =74=:375, 1913. [74] Pemberton, Ralph, and Sweet, J. E.: Further Studies on the Influence of the Ductless Glands on the Pancreas, Arch. Int. Med., May, 1910, p. 466. _Digestive Disturbances._--Secretin for digestive disturbance was first used in the “acid duodenal medication” of Enriquez.[75] This consisted in the giving of tartaric acid in thick keratin capsules, the acid not being liberated until the duodenum was reached, where it provoked the formation of secretin. “The secretin mechanism,” he says, “is probably capable of pathologic disturbance as would result, for example, with diminished acidity of chyme, disturbance of the normal motility of the stomach or pylorus, or diminished prosecretin in the mucosa. Such a condition would produce disturbance of the pancreatic, biliary and intestinal secretions, and interfere with intestinal movements, with a clinical syndrome of intestinal dyspepsia as a result, among the chief and most constant symptoms of which would be constipation.” “The acid duodenal medication” was submitted to wide clinical use, and very favorable results in certain obstinate cases of constipation were reported. In regard to “diminished prosecretin in the mucosa,” Wentworth[76] has claimed that in infantile atrophy such is the condition, but Sweet and Pemberton[77] have found that the difficulty of preparing secretin from human duodenums is such as to render Wentworth’s findings inconclusive. [75] Enriquez: Bull. du Lab. de biol. Appliq. 2, No. 2-No. 8, 1904. [76] Wentworth, A. H.: The Cause of Infantile Atrophy, J. A. M. A., July 20, 1907, p. 204. [77] Sweet, J. E., and Pemberton, Ralph: Experimental Observations on Secretin, Arch. Int. Med., February, 1908, p. 231.